| Identification | Back Directory | [Name]
Skp2 Inhibitor C1 | [CAS]
432001-69-9 | [Synonyms]
CS-1230
SKPin C1
MDK-1699
Skp2-IN-C1
kp2 Inhibitor C1
Skp2 Inhibitor C1
Skp2 inhibitor C1 (SKPin C1)
2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
Acetic acid, 2-[4-bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]- | [Molecular Formula]
C18H13BrN2O4S2 | [MDL Number]
MFCD03705291 | [MOL File]
432001-69-9.mol | [Molecular Weight]
465.34 |
| Chemical Properties | Back Directory | [Boiling point ]
655.3±65.0 °C(Predicted) | [density ]
1.74±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 10 mg/mL | [form ]
A crystalline solid | [pka]
2.97±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
SKPin C1 is a small molecule Skp-2-mediated p27 degradation inhibitor. | [Biological Activity]
Cell permeable: yes''Primary Target
disrupts p27-Skp2 interaction''Reversible: yes | [in vivo]
Skp2 Inhibitor C1 (5 mg/kg and 10 mg/kg; 3 times within 24 h: 24, 5, and 1 h before the test) shows the antidepressant-like effect in mouse models following chronic treatment by using the tail suspension test (TST), forced swimming test (FST), and social interaction test (SIT)[2].
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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