| Identification | Back Directory | [Name]
3-AMINO-5-BROMO-2-NITROPYRIDINE | [CAS]
433226-05-2 | [Synonyms]
5-BroMo-2-nitro-3-pyridinaMine
5-BroMo-2-nitropyridin-3-aMine
3-AMINO-5-BROMO-2-NITROPYRIDINE
3-Pyridinamine, 5-bromo-2-nitro-
5-Bromo-2-nitro-pyridin-3-ylamine | [Molecular Formula]
C5H4BrN3O2 | [MDL Number]
MFCD11040269 | [MOL File]
433226-05-2.mol | [Molecular Weight]
218.01 |
| Chemical Properties | Back Directory | [Boiling point ]
404.0±40.0 °C(Predicted) | [density ]
1.929±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
powder | [pka]
-3.55±0.25(Predicted) | [color ]
Very dark yellow | [InChI]
InChI=1S/C5H4BrN3O2/c6-3-1-4(7)5(8-2-3)9(10)11/h1-2H,7H2 | [InChIKey]
GOXZJSIRAHNQQG-UHFFFAOYSA-N | [SMILES]
C1([N+]([O-])=O)=NC=C(Br)C=C1N |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-amino-5-bromo-2-nitropyridine from ethyl (5-bromo-2-nitropyridin-3-yl)carbamate: to a solution of ethyl (5-bromo-2-nitropyridin-3-yl)carbamate (1.5 g, 5.2 mmol) in tetrahydrofuran (10 ml) was added a solution of potassium hydroxide (582 mg, 10.4 mmol) in water (5.0 ml) solution and the reaction mixture was stirred at 90°C overnight. After completion of the reaction, water was added to the mixture and precipitate was precipitated, the precipitate was collected by filtration, washed with water and then dried under reduced pressure to give 3-amino-5-bromo-2-nitropyridine (1.1 g, 95% yield). | [References]
[1] Patent: US2014/128391, 2014, A1. Location in patent: Paragraph 0226; 0231; 0232
[2] Patent: US2004/82583, 2004, A1
[3] Patent: US9242996, 2016, B2. Location in patent: Page/Page column 82; 83
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 19, p. 5913 - 5917
[5] Patent: WO2017/7756, 2017, A1. Location in patent: Paragraph 224 |
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