469-36-3

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469-36-3 Structure

Identification	Back Directory
[Name] ORYZANOL
[CAS] 469-36-3
[Synonyms] ORYZANOL Oryzanol C
[Molecular Formula] C41H60O4
[MDL Number] MFCD03457842
[MOL File] 469-36-3.mol
[Molecular Weight] 616.921

Chemical Properties	Back Directory
[Melting point ] 193-194 °C
[Boiling point ] 668.4±40.0 °C(Predicted)
[density ] 1.09±0.1 g/cm3(Predicted)
[storage temp. ] 4°C, protect from light
[form ] Solid
[pka] 8?+-.0.20(Predicted)
[color ] White to off-white

Hazard Information	Back Directory
[Uses] 24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor (EC50= 33.3μM)[1].
[IC 50] Akt1: 33.3 μM (EC₅₀)
[References] [1] Heon Woong Kim, et al. 24-Methylenecycloartanyl ferulate, a major compound of γ-oryzanol, promotes parvin-beta expression through an interaction with peroxisome proliferator-activated receptor-gamma 2 in human breast cancer cells. Biochem Biophys Res Commun. 2015 Dec 25;468(4):574-9. DOI:10.1016/j.bbrc.2015.10.147

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