| Identification | Back Directory | [Name]
2-((3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2-(hydroxymethyl)propane-1,3-diol | [CAS]
500015-20-3 | [Synonyms]
DCAP
DCAP >=95% (HPLC)
2-[3-(3,6-Dichloro-carbazol-9-yl)-2-hydroxy-propylamino]-2-hydroxymethyl-propane-1,3-diol
2-((3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2-(hydroxymethyl)propane-1,3-diol
1,3-Propanediol, 2-[[3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl]amino]-2-(hydroxymethyl)- | [Molecular Formula]
C19H22Cl2N2O4 | [MDL Number]
MFCD03084675 | [MOL File]
500015-20-3.mol | [Molecular Weight]
413.3 |
| Chemical Properties | Back Directory | [Boiling point ]
694.0±55.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
14.18±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
DCAP is a broad-spectrum antibiotic targeting the membranes of both Gram-positive and Gram-negative bacteria. DCAP blocks autophagy at the late stages by preventing autophagolysosome maturation and interrupting the autophagic flux[1]. | [Biological Activity]
DCAP is a potent broad-spectrum antibiotic th at specifically targets the membranes of both Gram-positive and Gram-negative bacteria. It reduces the transmembrane potential, kills stationary-phase cells and sterilizes bacterial biofilms. DCAP has no effect on red blood cell membranes at levels toxic to bacteria. | [References]
[1] Giulia Allavena, et al. A broad-spectrum antibiotic, DCAP, reduces uropathogenic Escherichia coli infection and enhances vorinostat anticancer activity by modulating autophagy. Cell Death Dis. 2018 Jul 13;9(7):780. DOI:10.1038/s41419-018-0786-4 |
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