| Identification | Back Directory | [Name]
5H-Cyclopenta[b]pyridine, 4-chloro-6,7-dihydro- | [CAS]
54664-55-0 | [Synonyms]
7-Dihydro-5H-cyclopenta[b]pyridine
6,7-Dihydro-5H-[1]pyrindin-4-ylaMine
5H-1-Pyrindine, 4-chloro-6,7-dihydro-
4-CHLORO-6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDINE
5H-Cyclopenta[b]pyridine, 4-chloro-6,7-dihydro-
4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine 98%
5H-Cyclopenta[b]pyridine, 4-chloro-6,7-dihydro- ISO 9001：2015 REACH | [Molecular Formula]
C8H8ClN | [MDL Number]
MFCD11113078 | [MOL File]
54664-55-0.mol | [Molecular Weight]
153.61 |
| Chemical Properties | Back Directory | [Boiling point ]
234℃ | [density ]
1.241 | [Fp ]
118℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
4.34±0.20(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
6,7-Dihydro-5H-cyclopenta[b]pyridine 1-oxide (2.5 g, 18 mmol) was mixed with phosphoryl chloride (20 mL, 200 mmol). The reaction mixture was stirred at 120 °C for 3 hours. Upon completion of the reaction, the excess POCl3 was removed by distillation under reduced pressure.The residue was diluted with 80 mL of EtOAc and neutralized to pH 7-8 with Na2CO3 solution.After filtration, the aqueous layer was extracted twice (40 mL each) with EtOAc. The organic extracts were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine (2.6 g, 93% yield). LCMS analysis: calculated value of C8H9ClN(M + H)+: m/z = 154.2; measured value: 154.3. | [References]
[1] Patent: US2014/200216, 2014, A1. Location in patent: Paragraph 0532; 0533
[2] Patent: US2014/200227, 2014, A1. Location in patent: Paragraph 0641; 0642
[3] Patent: WO2016/196244, 2016, A1. Location in patent: Page/Page column 195
[4] Patent: WO2009/19274, 2009, A1. Location in patent: Page/Page column 32
[5] Advanced Synthesis and Catalysis, 2007, vol. 349, # 14-15, p. 2345 - 2352 |
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