| Identification | Back Directory | [Name]
STE-MPKKKPTPIQLNP-NH2 | [CAS]
566872-15-9 | [Synonyms]
STE-MEK1(13)
STE-MPKKKPTPIQLNP-NH2
STEARYL-MEK-1 DERIVED PEPTIDE INHIBITOR 1, AMIDE
ERK ACTIVATION INHIBITOR PEPTIDE I, CELL-PERMEABLE
STE-MET-PRO-LYS-LYS-LYS-PRO-THR-PRO-ILE-GLN-LEU-ASN-PRO-NH2 | [Molecular Formula]
C86H153N19O17S | [MDL Number]
MFCD04974162 | [MOL File]
566872-15-9.mol | [Molecular Weight]
1757.32 |
| Hazard Information | Back Directory | [Uses]
STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH ) is a cell permeable ERK1/2 inhibitor (IC50: 13-30 μM). STE-MEK1(13) inhibits ERK1/2 phosphorylation[1][2]. | [Biological Activity]
Cell permeable: yes''Primary Target
MEK''Product does not compete with ATP.''Reversible: yes | [References]
[1] Li G, et al. A novel cellular survival factor--the B2 subunit of vacuolar H+-ATPase inhibits apoptosis. Cell Death Differ. 2006 Dec;13(12):2109-17. DOI:10.1038/sj.cdd.4401970
[2] Whiteman M, et al. Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells. Osteoarthritis Cartilage. 2006 May;14(5):460-70. DOI:10.1016/j.joca.2005.11.002 |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
AnaSpec, Inc.
|
| Tel: |
800 452 5530 |
| Website: |
www.anaspec.com |
|