| Identification | Back Directory | [Name]
OTAVA-BB 1207229 | [CAS]
571188-59-5 | [Synonyms]
POB02
OTAVA-BB
Ribociclib-2
PALBOCICLIB4
Palbociclib-11
Palbociclib-018
OTAVA-BB 1207229
)piperazine-1-carboxyL
Palbociclib side chain
Palbociclib Impurity 68
4-(6-aMinopyridin-3-yl)p
Palbociclib Intermediate
tert-butyl 4-(6-aMinopyri
Palbociclib's intermediate
Ribociclib Related Compound 1
1-Boc-4-(6-amino-3-pyridyl)piperazine
4-(6-Amino-3-pyridyl)-1-Boc-piperazine
1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZIN
1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE
4-(6-AMinopyridin-3-yl)-1-Boc-piperazine
4-(6-aMinopyridin-3-yl)piperazine-1-carboxylic
4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate)
1-Butyloxycarbonyl-4-(6-aminopyridin-3-yl)-piperazine
1-tert-Butoxycarbonyl-4-(6-amino-3-pyridyl)piperazine
Tert-Butyl 4-(6-aminopyridin-3-piperazine-1-carboxylate
Tert-buty 4-(6-amino-3-pyridyl)piperazine-1-carboxylate
6-(6-Aminopyridin-3-yl)piperazine, N1-BOC protected 98%
t-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate
OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine
ert-Butyl4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
1-(tert-Butoxycarbonyl)-4-(6-aminopyridin-3-yl)piperazine
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
tert-butyl 4-(6-aminoyridin-3-yl)pipera-zine-1-carboxylate
Tert-Butyl 4-(6-Amino-3-Pyrimidin)Piperazine-1-Carboxylate
tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >
tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
4-(6-aminopyridine-3-yl) piperazine-1-carboxylic tert-butyl ester
4-(6- aminopyridine -3- yl) piperazine -1- tert-butyl carboxylate
4-(6-Amino-3-pyridyl)piperazine-1-carboxylic Acid tert-Butyl Ester
2-Methyl-2-propanyl 4-(6-amino-3-pyridinyl)-1-piperazinecarboxylate
4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester
OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine(571188-59-5)
4- (6-aminopyridine-3-yl) piperazin-1-carboxylic acid tert-butyl ester
tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate(For Palbociclib)
OTAVA-BB 1207229
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
1-Piperazinecarboxylic acid, 4-(6-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester
Palbociclib Intermediate 1, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate | [EINECS(EC#)]
695-268-4 | [Molecular Formula]
C14H22N4O2 | [MDL Number]
MFCD11594962 | [MOL File]
571188-59-5.mol | [Molecular Weight]
278.354 |
| Chemical Properties | Back Directory | [Melting point ]
130-132℃ | [Boiling point ]
454.1±45.0 °C(Predicted) | [density ]
1.182 | [vapor pressure ]
0-0Pa at 20-25℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Very Slightly) | [form ]
Solid | [pka]
7.36±0.26(Predicted) | [color ]
Dark Yellow | [Sensitive ]
Air Sensitive | [InChI]
InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16) | [InChIKey]
RMULRXHUNOVPEI-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1 | [LogP]
1.6-1.8 at 35℃ and pH7-9 |
| Hazard Information | Back Directory | [Description]
Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer. | [Uses]
4-(6-Amino-3-pyridyl)-1-Boc-piperazine is used as an organic chemical synthesis intermediate. | [Preparation]
4- (6-Nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid ie f-butyl ester and Pd/C in ethanol is stirred with an H2 balloon for 3 h. The product tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is obtained through purification.
 | [Hazard]
Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation | [Synthesis]
General Steps:
Example 101h Synthesis of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 101h
To a 500 mL triple-necked vial under nitrogen protection was added tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate 101g (3.1 g, 10 mmol), 10% palladium-carbon catalyst (50% wet, 1.0 g) and anhydrous ethanol (100 mL). The reaction system was evacuated and filled with hydrogen, and the reaction was stirred at room temperature for 16 hours. Upon completion of the reaction, the hydrogen was removed by evacuation and refilled with nitrogen for protection. The reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure to give the target compound 101h (2.7 g, 97% yield). Mass spectral data: MS: [M + H]+ 279. | [References]
[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 6, p. 3125 - 3140
[2] Patent: WO2016/30439, 2016, A1. Location in patent: Page/Page column 30
[3] Patent: WO2011/140488, 2011, A1. Location in patent: Page/Page column 112; 270
[4] Patent: US2013/116262, 2013, A1. Location in patent: Paragraph 0315
[5] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0170; 0171; 1405 |
|
|