| Identification | Back Directory | [Name]
Benzoic acid, 4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]- | [CAS]
57343-54-1 | [Synonyms]
DQn-1
Benzoic acid, 4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]- | [Molecular Formula]
C16H14ClN5O2 | [MOL File]
57343-54-1.mol | [Molecular Weight]
343.77 |
| Hazard Information | Back Directory | [Uses]
DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 μM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1]. | [in vivo]
DQn-1 (5-10 mg/kg; p.o. for 8 days) fails to detect any significant reduction in Mtb burden of mice[1]. | [References]
[1] Kumar A, et, al. A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis. ACS Infect Dis. 2015 Dec 11;1(12):604-14. DOI:10.1021/acsinfecdis.5b00063 |
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