| Identification | Back Directory | [Name]
2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate) | [CAS]
57781-14-3 | [Synonyms]
Haloart
THS 201
Topicon
Ccris 2685
Einecs 260-951-4
halopredone acetate
Halopredone 17,21-diacetate
17,21-Bis(acetyloxy)-2-bromo-6β,9-difluoro-11β-hydroxypregna-1,4-diene-3,20-dione
17α,21-Bis(acetyloxy)-2-bromo-6β,9-difluoro-11β-hydroxypregna-1,4-diene-3,20-dione
17,21-Bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione
17,21-Bis(acetyloxy)-2-bromo-6-beta,9-difluoro-11-beta-hydroxypregna-1,4-dien-3,20-dione
2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate)
Pregna-1,4-diene-3,20-dione, 17,21-bis(acetyloxy)-2-bromo-6,9-difluoro-11-hydroxy-, (6β,11β)-
Pregna-1,4-diene-3,20-dione, 17,21-bis(acetyloxy)-2-bromo-6,9-difluoro-11-hydroxy-, (6beta,11beta)- | [EINECS(EC#)]
260-951-4 | [Molecular Formula]
C25H29BrF2O7 | [MDL Number]
MFCD00866011 | [MOL File]
57781-14-3.mol | [Molecular Weight]
559.39 |
| Chemical Properties | Back Directory | [Melting point ]
290-292° (dec) | [alpha ]
D24 -36° (c = 1 in chloroform) | [density ]
1.3611 (rough estimate) | [refractive index ]
1.3760 (estimate) |
| Hazard Information | Back Directory | [Originator]
Topicon,Pierrel,Italy,1983 | [Uses]
Anti-inflammatory (topical). | [Definition]
ChEBI: Halopredone acetate is an organic molecular entity. | [Manufacturing Process]
100 ml of a 70% hydrofluoric acid aqueous solution were cooled to -10°C in a
polyethylene flask equipped with electromagnetic stirrer. 10 g of 2-bromo-6β-
fluoro-17α,21-dihydroxy-9β, 11β-oxido-pregna-1,4-diene-3,20-dione-17,21-
diacetate were added under stirring during 15 minutes. After 0.5 hour the
reaction mixture was precipitated in water and ammonia. The solid was
collected by filtration, washed with water and dried to a constant weight,
giving about 9.5 g of 2-bromo-6β,9α-difluoro-11β,17α,21 -trihydroxypregna-
1,4-diene-3,20-dione-17,21-diacetate. | [Therapeutic Function]
Topical antiinflammatory |
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