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ChemicalBook--->CAS DataBase List--->620112-78-9

620112-78-9

620112-78-9 Structure

620112-78-9 Structure
IdentificationBack Directory
[Name]

alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile
[CAS]

620112-78-9
[Synonyms]

CCG-63802
CCG 63802; CCG63802
(E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)a
(E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)acry
α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile
2-Benzothiazoleacetonitrile, α-[[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-
alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile
(2E)-2-(1,3-Benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile
[Molecular Formula]

C26H18N4O2S
[MDL Number]

MFCD04190628
[MOL File]

620112-78-9.mol
[Molecular Weight]

450.51
Chemical PropertiesBack Directory
[Boiling point ]

547.9±60.0 °C(Predicted)
[density ]

1.31
[storage temp. ]

Sealed in dry,Store in freezer, under -20°C
[solubility ]

Limited solubility, soluble in DMSO
[form ]

solid
[pka]

-0.42±0.70(Predicted)
[color ]

Yellow
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

25
[Safety Statements ]

45
Hazard InformationBack Directory
[Uses]

CCG-63802 may be used to study G-protein-mediated cell signaling.
[Biological Activity]

CCG-63802 is a selective, reversible inhibitor of the G protein signaling regulator RGS4. It specifically binds to RGS4 and blocks RGS4-Gαo interaction with IC50 value of 1.9 μM.
[in vitro]

CCG-63802 (5 μM) inhibits regulators of G-protein signaling (RGS) proteins in the presence of BK (bradykinin) and 8-Br-cGMP (membrane-permeable analogue of cGMP), HEK-293 cells start to depolarize again.

[in vivo]

CCG-63802 (0.05 mg/kg; intratracheal administration; once per week; 90 days) reduces RGS4 protein expression, leading to partially abrogate the attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodeling .
[target]

RGS4

1.9 μM (IC 50 )

[IC 50]

RGS4: 1.9 μM (IC50)
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