| Identification | Back Directory | [Name]
2-METHYL-QUINOLINE-3-CARBOXYLIC ACID | [CAS]
635-79-0 | [Synonyms]
Quinaldine-3-carboxylic acid
3-Quinolinecarboxylic acid, 2-methyl-
Synthesis of 2-Methylquinolin-3-amine
2-Methylquinoline-3-carboxylic acid 95% | [EINECS(EC#)]
655-167-8 | [Molecular Formula]
C11H9NO2 | [MDL Number]
MFCD00510998 | [MOL File]
635-79-0.mol | [Molecular Weight]
187.19 |
| Chemical Properties | Back Directory | [Melting point ]
251 °C | [Boiling point ]
342.0±27.0 °C(Predicted) | [density ]
1.285±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
solid | [pka]
1.17±0.30(Predicted) | [color ]
Light brown to brown | [InChI]
InChI=1S/C11H9NO2/c1-7-9(11(13)14)6-8-4-2-3-5-10(8)12-7/h2-6H,1H3,(H,13,14) | [InChIKey]
WXYKQNAKEPRCGF-UHFFFAOYSA-N | [SMILES]
N1C2C(=CC=CC=2)C=C(C(O)=O)C=1C |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-methyl-3-quinolinecarboxylic acid from ethyl 2-methylquinoline-3-carboxylate: to a stirred 60% aqueous ethanol solution (80 mL) of potassium hydroxide (4.489 g, 80 mmol) was added ethyl 2-methylquinoline-3-carboxylate (2.153 g, 10 mmol). The reaction mixture was stirred under reflux conditions for 1 hour. Upon completion of the reaction, the ethanol was evaporated under reduced pressure, followed by dilution with the addition of water (10 mL) and acidification with 1 M hydrochloric acid solution to pH < 7. The precipitate precipitated was collected and recrystallized by a solvent mixture of dichloromethane/hexane (1:10, v/v) to give 2-methyl-3-quinolinecarboxylic acid as a yellow solid in 92% yield (1.724 g, 9.2 mmol). | [References]
[1] Synthesis (Germany), 2013, vol. 45, # 23, p. 3239 - 3244
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 23, p. 6897 - 6907 |
|
| Company Name: |
SynAsst Chemical.
|
| Tel: |
021-60343070 |
| Website: |
www.approvedhomemanagement.com/ShowSupplierProductsList15848/0_EN.htm |
|