| Identification | Back Directory | [Name]
VAR10300 dihydrochloride | [CAS]
64821-19-8 | [Synonyms]
M30 dihydrochloride
M-30 dihydrochloride
VAR10300 dihydrochloride
MAO-IN-M30 dihydrochloride
5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride
5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride
N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride | [Molecular Formula]
C14H16Cl2N2O | [MDL Number]
MFCD20488063 | [MOL File]
64821-19-8.mol | [Molecular Weight]
299.196 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO, heptane and xylene: ≥21mg/mL | [form ]
powder | [color ]
green-yellow | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
M 30 Dihydrochloride is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA (Cat. No. 2547) induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson''s disease model. | [Biological Activity]
M30 is a site-activated iron chelator and monoamine oxidase (MAO) inhibitor; with neuroprotective and anti-apoptotic activity. It is a multifunctional non-toxicbrain permeable iron chelator possessing a neuroprotective propargylamine moiety and an antioxidant-iron chelator moiety. M30 is a selective irreversible inhibitor of mitochondrial brain monoamine oxidases A and B (MAO-A and -B)providing for improved levels of neurotransmitters. It reduces oxidative damage and shows neuroprotective and neurorestorative effects in various neurodegenerative models of ALSAlzheimerμs and Parkinsonμs diseasesand is being investigated in other diseases where oxidative stress is a problem. | [in vivo]
MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities[6]. | Animal Model: | Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)[6] | | Dosage: | 0.5, 2.5 mg/kg | | Administration: | P.o.; once daily for 14 consecutive days | | Result: | Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.
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| [IC 50]
MAO-A: 37 nM (IC50); MAO-B: 57 nM (IC50) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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