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ChemicalBook--->CAS DataBase List--->67508-09-2

67508-09-2

67508-09-2 Structure

67508-09-2 Structure
IdentificationBack Directory
[Name]

N-dimethylaminoprostaglandin F2alpha
[CAS]

67508-09-2
[Synonyms]

Prostaglandin F2α dimethyl amine
N-dimethylaminoprostaglandin F2alpha
Prosta-5,13-diene-9,11,15-triol, 1-(dimethylamino)-, (5Z,9α,11α,13E,15S)- (9CI)
(1R,3S,4R,5R)-4-[(Z)-7-(dimethylamino)hept-2-enyl]-5-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentane-1,3-diol
[Molecular Formula]

C22H41NO3
[MOL File]

67508-09-2.mol
[Molecular Weight]

367.57
Chemical PropertiesBack Directory
[solubility ]

DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >20 mg/ml; Methyl acetate: <10 mg/ml; PBS pH 7.2: >3 mg/ml
Hazard InformationBack Directory
[Description]

PGF dimethyl amine is a derivative of PGF which was designed as a PG antagonist for in vitro and in vivo studies. PGF dimethyl amine is a weak FP receptor antagonist. In gerbil colon, PGF dimethyl amine at a dose of 3.2 μg/ml inhibits the contractile effects of PGF (at 6 ng/ml) by 60%.
[Uses]

Prostaglandin F2α dimethyl amine is a Prostaglandin F2α (HY-12956) derivative. Prostaglandin F2α dimethyl amine is an antagonist for Prostaglandin F receptor (FP)[1]. Prostaglandin F2α dimethyl amine blocks the cardiovascular responses induced by orexin and Arachidonic acid (HY-109590)[2].
[Definition]

ChEBI: A member of the class of prostaglandins Falpha that is the dimethylamine derivative of prostaglandin F2alpha.
[in vivo]

Prostaglandin F2α dimethyl amine (50 μg, i.c.v., single dose) prevents the pressor and tachycardic effects induced by Orexin in Sprague-Dawley rats[2].

Animal Model: Orexin-induced cardiovascular response in Sprague Dawley rats[2]
Dosage:50 μg
Administration:i.c.v for single dose
Result:Prevented the pressor and tachycardic effects.
[IC 50]

FP
[References]

[1] Griffin BW, et al., AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. J Pharmacol Exp Ther. 1999 Sep;290(3):1278-84. PMID:10454504
[2] ALTINBA? B. The Intermediation Role of Central Cyclooxygenase Products TXA2, PGF2α, PGE, and PGD in Orexin-evoked Cardiovascular Effects[J]. Izmir Democracy University Health Sciences Journal, 2021, 4(3): 251-266.
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