| Identification | Back Directory | [Name]
GM-608 | [CAS]
725715-18-4 | [Synonyms]
GM-602
GM-603
GM-604
GM-605
GM-606
GM-607
GM-608
Alirinetide
GM608,GM 608
L-Arginine, L-phenylalanyl-L-seryl-L-arginyl-L-tyrosyl-L-alanyl- | [Molecular Formula]
C36H54N12O9 | [MOL File]
725715-18-4.mol | [Molecular Weight]
798.89 |
| Hazard Information | Back Directory | [Uses]
Alirinetide (GM604) is an oligopeptide containing 6 amino acids. Alirinetide can cross the blood-brain barrier and can be used for the research of multiple neurodegenerative diseases[1]. | [in vivo]
Alirinetide (GM604) (0-20 mg/kg; i.v.; twice daily for 5 days) improves behavioral, biochemical, and histological features in the 6-OHDA mouse model[1]. | Animal Model: | C57BL/6 mice, 6-hydroxydopamine (6-OHDA) mouse model[1] | | Dosage: | 0, 1, 5, 10 or 20 mg/kg | | Administration: | Intravenous injection, twice daily for 5 days | | Result: | Almost completely abrogated 6-OHDA effects at the highest dose, leading to improved motor performance, increased numbers of TH-positive neurons in the substantia nigra, and increased brain levels of dopamine, 3,4-Dihydroxyphenylacetic acid (DOPAC) and
homovanillic acid (HVA).
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| [References]
[1] Swindell W R, et al. GM604 for Parkinson's Disease treatment: Pre-clinical findings and results from a pilot placebo-controlled trial. F1000Research, 2017, 6. |
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