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Veltuzumab (IMMU-106) is a humanized anti-CD20 monoclonal antibody. Veltuzumab has low EC50 value of 0.08-0.09 μg/mL in the Daudi cell line. Veltuzumab can be used for the research of cancer including non-Hodgkin lymphoma (NHL)[1]. | [in vivo]
Veltuzumab (i.v. or s.c.; 5, 20 and 60 μg; single) can control tumor growth or deplete circulating or sessile B cells at low doses in mouse models of intraperitoneal and subcutaneous doses[1].
Veltuzumab (i.p.; 0.05-35 μg) are significantly effective in vivo[1]. | Animal Model: | Lymphoma xenograft model[1] | | Dosage: | 5, 20 and 60 μg | | Administration: | intraperitoneal and subcutaneous, single | | Result: | Showed low dose of 0.05 μg increased the MST. |
| Animal Model: | SCID mice[1] | | Dosage: | 0.5, 0.25, 0.1, or 0.05 μg; 35, 3.5, 0.35, or 0.035 μg | | Administration: | intraperitoneal, single | | Result: | Improved significantly survival. |
| [References]
[1] David M Goldenberg, et al. Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody. Blood DOI:10.1182/blood-2008-07-168146 |
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SPIRO PHARMA
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Biolab Reagents
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