| Identification | Back Directory | [Name]
MPEG7-NHS | [CAS]
756525-90-3 | [Synonyms]
MPEG7-NHS
mPEG7-SPA
MeO-dPEG(8)-NHS
m-PEG8-NHS ester
m-dPEG8-NHS ester
m-dPEG(R)8-NHS ester
Methyl-PEG8-NHS Ester
Methyl-PEG7-NHS ester
MPEG7-CH2CH2COONHS Ester
Methyl-PEG8-NHS Ester
N-Succinimidyl 4,7,10,13,16,19,22,25-Octaoxahexacosanoate
4,7,10,13,16,19,22,25-Octaoxahexacosanoic Acid N-Succinimidyl Ester
1-[(1-Oxo-4,7,10,13,16,19,22,25-octaoxahexacos-1-yl)oxy]-2,5-pyrrolidinedione
4,7,10,13,16,19,22,25-Octaoxahexacosanoic acid 2,5-dioxo-1-pyrrolidinyl ester
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate | [Molecular Formula]
C22H39NO12 | [MDL Number]
MFCD13184969 | [MOL File]
756525-90-3.mol | [Molecular Weight]
509.545 |
| Chemical Properties | Back Directory | [storage temp. ]
<0°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
solid or viscous liquid | [color ]
Colorless to Yellow | [InChI]
InChI=1S/C22H39NO12/c1-27-6-7-29-10-11-31-14-15-33-18-19-34-17-16-32-13-12-30-9-8-28-5-4-22(26)35-23-20(24)2-3-21(23)25/h2-19H2,1H3 | [InChIKey]
IBZNTYBFTKFSMU-UHFFFAOYSA-N | [SMILES]
C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCOCCOCCOCCOC | [CAS DataBase Reference]
756525-90-3 |
| Hazard Information | Back Directory | [Description]
m-PEG8-NHS ester is a PEG linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG8-NHS ester is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | [reaction suitability]
reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: amine reactive | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
| [References]
[1] By Boehnke, et al. Preparation of antibody drug conjugates with NAMPT inhibitors for use in treatment of cancer. Patent WO2019149637A1. |
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