| Identification | Back Directory | [Name]
2-Chloro-1-propanol | [CAS]
78-89-7 | [Synonyms]
VPM-4G
Nsc122672
2-Chloropropanol
2-chloro-1-propano
MONOCHLOROPROPANOL
2-Chloro-1-propanol
2-chloropropan-1-ol
2-chloro-propan-1-ol
PROPYLENECHLORHYDRIN
1-Propanol, 2-chloro-
2-chloropropylalcohol
Verapamil Impurity 21
2-Chloropropyl alcohol
1-Hydroxy-2-chloropropane
beta-Chloropropyl alcohol
1,2-Propylenechlorohydrine
1,2-PROPYLENE CHLOROHYDRIN | [EINECS(EC#)]
201-154-3 | [Molecular Formula]
C3H7ClO | [MDL Number]
MFCD01941467 | [MOL File]
78-89-7.mol | [Molecular Weight]
94.5401 |
| Chemical Properties | Back Directory | [Appearance]
Colorless liquid; mild, nonresidual odor.
Soluble in water and alcohol.
| [Melting point ]
<25 °C | [Boiling point ]
bp 133-134° | [density ]
d20 1.103 | [refractive index ]
nD20 1.4362 | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Sparingly) | [form ]
Oil | [pka]
14.16±0.10(Predicted) | [color ]
Colourless | [Odor]
pleasant odor | [Exposure limits]
No exposure limit is set. However, on the
basis of its similar toxic properties to ethylene chlorohydrin, a TLV-TWA air 10 ppm
(approximately 40 mg/m3) is recommended. | [LogP]
0.268 (est) | [CAS DataBase Reference]
78-89-7 | [EPA Substance Registry System]
2-Chloro-1-propanol (78-89-7) |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless liquid; mild, nonresidual odor.
Soluble in water and alcohol.
| [Uses]
In preparation of propylene oxide, q.v. | [General Description]
Clear colorless liquid with a pleasant odor. | [Air & Water Reactions]
Water soluble. | [Reactivity Profile]
2-Chloro-1-propanol may be sensitive to prolonged exposure to light. 2-Chloro-1-propanol can react with oxidizing agents. . | [Fire Hazard]
2-Chloro-1-propanol is flammable. | [Hazard]
Moderate fire risk. Toxic by ingestion and
skin absorption. Liver damage. Questionable car-
cinogen.
| [Potential Exposure]
This material is used in organic
synthesis; to make other chemicals. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts
the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention
immediately. If this chemical has been inhaled, remove
from exposure, begin rescue breathing (using universal
precautions, including resuscitation mask) if breathing has
stopped and CPR if heart action has stopped. Transfer
promptly to a medical facility. When this chemical
has been swallowed, get medical attention. Give large
quantities of water and induce vomiting. Do not make
an unconscious person vomit. | [Shipping]
UN2611Propylene chlorohydrin, Hazard class:
6.1; Labels: 6.1-Poisonous materials, 3-Flammable liquid. | [Incompatibilities]
Vapor may form explosive mixture
with air. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides. Alcohols are sensitive to light and oxi-
dation. It is unstable in solution. It undergoes hydrolysis in
aqueous buffers. Contact with alkali metals, nitrides, and
strong reducing agents may form flammable and/or toxic
gases. May react with anhydrides forming acids and esters,
generating noticeable heat, and also with oxoacids and
carboxylic acids to form esters plus water, but the heat
of reaction in the latter case typically is low. May initiate
the polymerization of isocyanates and epoxides. | [Waste Disposal]
Dissolve or mix the
material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber.
All federal, state, and local environmental regulations must
be observed. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 72, p. 4353, 1950 DOI: 10.1021/ja01166a005 | [Health Hazard]
Propylene β-chlorohydrin is a moderatelytoxic compound having irritant actions onthe skin and eyes. Instilling 2.2 mg of liquidcaused severe eye irritation in rabbits. It cancause poisoning via ingestion, inhalation, andskin absorption. Exposure to 500 ppm for4 hours was lethal to rats. The lethal dosein dogs by oral intake was 200 mg/kg. Thetarget organs are the CNS, gastrointestinalsystem, liver, and kidney.
LD50 value, skin (rabbits): 529 mg/kg
Studies conducted to determine increasedrisks of pancreatic and lymphopoietic can cer among workers in ethylene and propylene chlorohydrin production remained inconclu sive and have given inconsistent findings(Olsen et al. 1997). |
| Safety Data | Back Directory | [RIDADR ]
2611 | [HazardClass ]
6.1(a) | [PackingGroup ]
II | [Safety Profile]
Poison by ingestion.
Moderately toxic by inhalation and skin
contact. A skin and severe eye irritant.
Flammable liquid when exposed to heat,
flame, or powerful oxidizers. To fight fire,
use alcohol foam, CO2, dry chemical. When
heated to decomposition it emits toxic
fumes of Cl-. | [Hazardous Substances Data]
78-89-7(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: 0.22 ml/kg; by skin penetration in rabbits: 0.48 ml/kg, Smyth et al., Am. Ind. Hyg. Assoc. J. 30, 470 (1969) |
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