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ChemicalBook--->CAS DataBase List--->836620-48-5

836620-48-5

836620-48-5 Structure

836620-48-5 Structure
IdentificationBack Directory
[Name]

AS1842856
[CAS]

836620-48-5
[Synonyms]

CS-2538
AS1842856
AS 1842856;AS-1842856
5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
3-Quinolinecarboxylic acid, 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-
[Molecular Formula]

C18H22FN3O3
[MOL File]

836620-48-5.mol
[Molecular Weight]

347.38
Chemical PropertiesBack Directory
[Boiling point ]

587.3±50.0 °C(Predicted)
[density ]

1.370±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
[solubility ]

DMSO:5.0(Max Conc. mg/mL);14.39(Max Conc. mM)
[form ]

A crystalline solid
[pka]

6.47±0.50(Predicted)
[color ]

White to light yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07,GHS08,GHS09
[Signal word ]

Danger
[Hazard statements ]

H302-H410-H372
[Precautionary statements ]

P260-P264-P273-P501
Hazard InformationBack Directory
[Description]

AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1; IC50 = 33 nM in HepG2 cells). Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and inhibits glucogenesis in rat hepatoma Fao cells and a murine model of type 2 diabetes mellitus (T2DM). AS-1842856 also inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes.,
[Uses]

AS 1842856 is a novel FoxO1 antagonist with anti-obesity effects.
[Definition]

ChEBI: AS1842856 is a quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. It has a role as a hypoglycemic agent, an anti-obesity agent, an autophagy inhibitor, an antineoplastic agent, an apoptosis inducer and a forkhead box protein O1 inhibitor. It is a quinolinemonocarboxylic acid, a quinolone, an organofluorine compound, a primary amino compound, a secondary amino compound and a tertiary amino compound.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

AS1842856(836620-48-5)1HNMR
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