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ChemicalBook--->CAS DataBase List--->859209-74-8

859209-74-8

859209-74-8 Structure

859209-74-8 Structure
IdentificationBack Directory
[Name]

GS-9219
[CAS]

859209-74-8
[Synonyms]

GS-9219
VDC-1101
Rabacfosadine
GS-9219 Rabacfosadine
[Molecular Formula]

C21H35N8O6P
[MDL Number]

MFCD23704866
[MOL File]

859209-74-8.mol
[Molecular Weight]

526.53
Chemical PropertiesBack Directory
[Boiling point ]

733.9±70.0 °C(Predicted)
[density ]

1.50±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

4.81±0.10(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Rabacfosadine (GS-9219), a novel proagent of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells.
[in vivo]

Rabacfosadine (RAB) has substantial single-agent activity in dogs with lymphoma, and a different mechanism of action than Doxorubicin (DOX). Open-label, multicenter prospective clinical trial. Dogs receive alternating Rabacfosadine (1.0 mg/kg IV weeks 0, 6, 12) and Doxorubicin (30 mg/m2 IV weeks 3, 9, 15). Dogs that achieved complete response (CR) are followed by monthly evaluations. Complete clinicopathological evaluation and assessment of remission and adverse event (AEs) are performed every 21 days. Acute AEs, occurring within 21 days after administration of the first dose of each agent, are compared between Rabacfosadine and Doxorubicin in 46 dogs receiving at least 1 dose of each agent[2].

[References]

[1] Reiser H, et al. GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma. Clin Cancer Res. 2008 May 1;14(9):2824-32. DOI:10.1158/1078-0432.CCR-07-2061
[2] Thamm DH, et al. Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Na?ve Canine Multicentric Lymphoma. J Vet Intern Med. 2017 May;31(3):872-878. DOI:10.1111/jvim.14700
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