Identification | Back Directory | [Name]
2-Morpholinopyrimidin-5-ylboronic acid | [CAS]
870521-33-8 | [Synonyms]
2-Morpholinopyrimidine-5-boronic acid 2-morpholino-5-pyrimidineboronic acid 2-morpholinopyrimidin-5-ylboronic acid 2-Morpholinopyrimidin-5-ylboronic acid 95% 2-(Morpholine-4-yl)pyrimidine-5-boronic acid [2-(4-Morpholinyl)-5-pyrimidinyl]boronic acid Boronic acid,B-[2-(4-morpholinyl)-5-pyrimidinyl]- | [Molecular Formula]
C8H12BN3O3 | [MDL Number]
MFCD07375148 | [MOL File]
870521-33-8.mol | [Molecular Weight]
209.01 |
Chemical Properties | Back Directory | [Boiling point ]
484.0±55.0 °C(Predicted) | [density ]
1.37 | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
solid | [pka]
3.02±0.19(Predicted) | [Appearance]
White to yellow Solid |
Hazard Information | Back Directory | [Synthesis]
The reaction was carried out with 2-chloropyrimidin-5-ylboronic acid (1 g, 6.32 mmol), morpholine (2.19 mL, 25.26 mmol) and triethylamine (0.88 mL, 6.32 mmol) in ethanol (25 mL) with stirring for 1 hour at 20 °C. After completion of the reaction, water (50 mL) was slowly added to the reaction mixture. The resulting precipitate was collected by filtration and washed with water to finally obtain 2-morpholinopyrimidin-5-ylboronic acid (950 mg, 70% yield) as a milky white solid. The NMR hydrogen spectrum (250 MHz, DMSO-d6) data were as follows: δ 8.63 (s, 2H), 8.05 (s, 2H), 3.68 (ddd, J=23.4,5.7,3.9Hz, 8H). | [References]
[1] Patent: WO2015/86506, 2015, A1. Location in patent: Page/Page column 131 [2] Patent: WO2015/86512, 2015, A1. Location in patent: Page/Page column 102 [3] Patent: WO2015/86527, 2015, A1. Location in patent: Page/Page column 114; 115 [4] Patent: WO2015/86526, 2015, A1. Location in patent: Page/Page column 147 [5] Patent: WO2015/86525, 2015, A1. Location in patent: Page/Page column 121; 122 |
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Company Name: |
Shanghai Ennopharm Co., Ltd.
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Tel: |
+86 (21) 6435-5022 |
Website: |
www.approvedhomemanagement.com/ShowSupplierProductsList13640/0_EN.htm |
Company Name: |
NovoChemy Ltd.
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Tel: |
021-31261262/ 49 (0)17662837245 |
Website: |
www.novochemy.com |
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