110-91-8

1003845-06-4

870521-33-8

The reaction was carried out with 2-chloropyrimidin-5-ylboronic acid (1 g, 6.32 mmol), morpholine (2.19 mL, 25.26 mmol) and triethylamine (0.88 mL, 6.32 mmol) in ethanol (25 mL) with stirring for 1 hour at 20 °C. After completion of the reaction, water (50 mL) was slowly added to the reaction mixture. The resulting precipitate was collected by filtration and washed with water to finally obtain 2-morpholinopyrimidin-5-ylboronic acid (950 mg, 70% yield) as a milky white solid. The NMR hydrogen spectrum (250 MHz, DMSO-d6) data were as follows: δ 8.63 (s, 2H), 8.05 (s, 2H), 3.68 (ddd, J=23.4,5.7,3.9Hz, 8H).