| Identification | Back Directory | [Name]
Trityl-PEG9-Azide | [CAS]
877239-08-2 | [Synonyms]
Trityl-PEG9-N3
Trityl-PEG9-Azide
Trityl-PEG10-Azide | [Molecular Formula]
C39H55N3O10 | [MDL Number]
MFCD22683292 | [MOL File]
877239-08-2.mol | [Molecular Weight]
725.88 |
| Hazard Information | Back Directory | [Description]
Trityl-PEG10-azide is a PEG linker containing an azide group and a trityl protected ester. Trityl group can be removed under acid conditions or hydrogenolysis. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Trityl-PEG10-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Trityl-PEG10-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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