| Identification | Back Directory | [Name]
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene | [CAS]
898566-17-1 | [Synonyms]
Canagliflozin INT5
2-(4-Fluorophenyl)
)-5-(5-iodo-2-methyL
Canagliflozin iMpurity D
-5-(5-iodo-2-methylbenzyl)
Canagliflozin Intermediate1
2-(4-Fluorophenyl)-5-(5- iodo-methylphenyI) metl
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]
2-(4-Fluorophenyl)-5-(5-iodo-2-Methylbenzyl)thiophene
2-(4-Fluorophenyl)-5-(5-iodo-methylphenyl) methyl] thiophene
2-(4-Fluoropheny1)-5-[(5-iodo-2 methylphenyl)methyl]thiophene
2-((5-IODO-2-METHYLPHENYL)METHYL)-5-(4-FLUOROPHENYL)THIOPHENE
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
2-(4-Flurophenyl)-5-[(5-Iodo-2-methylphenyl] methyl] Thiophene
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophen...
Thiophene, 2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]-
2-(4-FLUOROPHENYL)-5-[(5-IODO-2-METHYLPHENYL)METHYL]THIOPHENE 898566-17-1
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene cas 898566-17-1
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene ISO 9001：2015 REACH
Canagliflozin impurity-(2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)
Canagliflozin intermediates，2-(4-Fluorophenyl)-5-[(5-iodo-2- methylphenyl)methyl]thiophene
Canagliflozin impurity DQ: What is
Canagliflozin impurity D Q: What is the CAS Number of
Canagliflozin impurity D Q: What is the storage condition of
Canagliflozin impurity D | [EINECS(EC#)]
618-312-6 | [Molecular Formula]
C18H14FIS | [MDL Number]
MFCD12405593 | [MOL File]
898566-17-1.mol | [Molecular Weight]
408.27 |
| Chemical Properties | Back Directory | [Melting point ]
109-110 °C | [Boiling point ]
450.2±45.0 °C(Predicted) | [density ]
1.533 | [vapor pressure ]
0-0Pa at 20-25℃ | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO (Sparingly), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Yellow | [InChI]
InChI=1S/C18H14FIS/c1-12-2-7-16(20)10-14(12)11-17-8-9-18(21-17)13-3-5-15(19)6-4-13/h2-10H,11H2,1H3 | [InChIKey]
MGXZKAYHSITHMW-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=C(F)C=C2)SC(CC2=CC(I)=CC=C2C)=CC=1 | [LogP]
7.5 at pH7 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid. | [Uses]
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene is an antidiabetic agent and a Canagliflozin (C175190) intermediate. Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and a candidate for the treatment of type 2 diabetes and obesity. | [Synthesis]
2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene (100 g; cf. WO 2005/012326) was dissolved in toluene (300 mL) at room temperature and under nitrogen atmosphere. To this solution, sodium iodide (83 g), cuprous(I) iodide (2.64 g), N,N'-dimethylethylenediamine (2.94 mL) and diethylene glycol dimethyl ether (50 mL) were added sequentially. The reaction mixture was heated to reflux temperature and stirred continuously for 36 hours. Upon completion of the reaction, ethyl acetate (300 mL) was added to the mixture at 40 °C and filtered through a filter pre-coated with activated carbon. The filtrate was washed and concentrated. The resulting residue was suspended in methanol (426 mL) at reflux temperature for 75 minutes. Subsequently, the suspension was cooled to 25 °C and stirring was continued for 1 hour. The precipitate was collected by filtration, washed with methanol and dried under vacuum at 50 °C to afford 2-(5-iodo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene (94.9 g) in white crystalline form. The mass spectrum (APCI) showed a m/z of 409 (M + H); the melting point was 109-110°C. The crystal was found to have the following properties. | [References]
[1] Patent: WO2009/35969, 2009, A1. Location in patent: Page/Page column 77
[2] Patent: US2010/99883, 2010, A1. Location in patent: Page/Page column 43
[3] Patent: US2016/228375, 2016, A1. Location in patent: Paragraph 0097; 0098 |
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