| Identification | Back Directory | [Name]
Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate | [CAS]
902589-96-2 | [Synonyms]
YMU1
Thymidylate Kinase Inhibitor, YMU1
Thymidylate Kinase Inhibitor, YMU1 - CAS 902589-96-2 - Calbiochem
Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate
4-[2-(4,6-Dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl]-1-piperazinecarboxylic acid ethyl ester
1-Piperazinecarboxylic acid, 4-[2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl]-, ethyl ester | [Molecular Formula]
C17H22N4O4S | [MDL Number]
MFCD27952931 | [MOL File]
902589-96-2.mol | [Molecular Weight]
378.45 |
| Hazard Information | Back Directory | [Uses]
YMU1 is a potent, reversible, and ATP-competitive inhibitor of human Thymidylate kinase (TMPK). | [Biological Activity]
YMU1 is a cell-permeable and nontoxic inhibitor of hTMPK (thymidylate kinase) th at sensitizes tumor cells to doxorubicin in vitro and in vivo. | [in vivo]
YMU1 (5 mg/kg, intraperitoneal injection, three times a week, for 25 days) and doxorubicin co-administered to mice inhibits tumor growth[1].
YMU1 (3-10 mg/kg, intraperitoneal injection, once every two days, for 30 days) inhibits the growth of A549 xenograft tumors in mice[2]. | Animal Model: | HCT-116 p53-/- cell transplantation model in nude mice[1] | | Dosage: | 5 mg/kg; 3 times a week; 25 days | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Showed that tumors grew significantly slower in mice treated with doxorubicin. |
| Animal Model: | A549 nude mouse transplantation model[2] | | Dosage: | 3,10 mg/kg; once every two days; 30 days | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Reduced tumor volume and weight in a dose-dependent manner. |
| [IC 50]
STAT3 |
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