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ChemicalBook--->CAS DataBase List--->935283-04-8

935283-04-8

935283-04-8 Structure

935283-04-8 Structure
IdentificationBack Directory
[Name]

Linzagolix
[CAS]

935283-04-8
[Synonyms]

Linzagolix
Thieno[3,4-d]pyrimidine-5-carboxylic acid, 3-[5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-2-fluoro-4-methoxyphenyl]-1,2,3,4-tetrahydro-2,4-dioxo-
[Molecular Formula]

C22H15F3N2O7S
[MOL File]

935283-04-8.mol
[Molecular Weight]

508.42
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 125 mg/mL (245.86 mM; Need ultrasonic)
[form ]

Solid
[color ]

White to light brown
[InChIKey]

BMAAMIIYNNPHAB-UHFFFAOYSA-N
[SMILES]

C1(=O)N(C2=CC(OCC3=C(OC)C=CC(F)=C3F)=C(OC)C=C2F)C(=O)C2=C(C(O)=O)SC=C2N1
Hazard InformationBack Directory
[Uses]

Linzagolix (KLH-2109; OBE-2109) is a potent, non-peptide, and orally active GnRH antagonist. Linzagolix can be used for uterine fibroids, endometriosis, adenomyosis research[1][2][3].
[in vivo]

Linzagolix (50 mg/kg) reduces cyst volume in a rat model of endometriosis[1].
Lindagolix reduces serum luteinizing hormone and testosterone levels in male rats and dogs with normal or BPH models[2].

Animal Model:Endometriosis model rat[1]
Dosage:50 mg/kg
Administration:
Result:Reduced cyst volume.
[References]

[1] Motohiro Tezuka, et al. Suppressive effects of linzagolix, a novel non-peptide antagonist of gonadotropin-releasing hormone receptors, in experimental endometriosis model rats. Clin Exp Pharmacol Physiol. 2023 Jul;50(7):610-617. DOI:10.1111/1440-1681.13778
[2] Motohiro Tezuka, et al. Suppression of hypothalamic-pituitary-gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models. Clin Exp Pharmacol Physiol. 2023 Nov;50(11):914-923. DOI:10.1111/1440-1681.13817
[3] Susan Dababou, et al. Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine myomas. Expert Opin Investig Drugs. 2021 Sep;30(9):903-911. DOI:10.1080/13543784.2021.1957830
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