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ChemicalBook--->CAS DataBase List--->94376-75-7

94376-75-7

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    94376-75-7 Structure

    94376-75-7 Structure
    IdentificationBack Directory
    [Name]

    alpha, oMega-Dipropionic acid hexaethylene glycol
    [CAS]

    94376-75-7
    [Synonyms]

    94376-75-7
    Bis-PEG7-COOH
    Bis-PEG7-acid
    Bis-PEG8-acid
    HOOC-PEG6-COOH
    COOH-PEG6-COOH
    COOH-PEG7-COOH
    Bis(3-PEG6)propionic acid
    HOOCCH2CH2O-PEG6-CH2CH2COOH
    α,ω-Dipropionic acid hexaethylene glycol
    4,7,10,13,16,19,22-Heptaoxapentacosanedioic acid
    alpha, oMega-Dipropionic acid hexaethylene glycol
    3-(2-{2-[2-(2-{2-[2-(2-Carboxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-ethoxy)propionic acid
    [Molecular Formula]

    C18H34O11
    [MDL Number]

    MFCD11041125
    [MOL File]

    94376-75-7.mol
    [Molecular Weight]

    426.46
    Chemical PropertiesBack Directory
    [form ]

    Viscous Liquid
    [color ]

    Colorless to light yellow
    Safety DataBack Directory
    [Symbol(GHS) ]


    GHS07
    [Signal word ]

    Warning
    [Hazard statements ]

    H302-H315-H319-H335
    [Precautionary statements ]

    P261-P305+P351+P338
    Hazard InformationBack Directory
    [Description]

    Bis-PEG7-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
    [Uses]

    Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
    [Biological Activity]

    Bis-PEG7-acid is a PROTAC linker belonging to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
    [target]

    PEGs

    Cleavable

    [IC 50]

    PEGs; Cleavable Linker
    [References]

    [1] Marc Stefan ROBILLARD, et al. Tetrazines for high click conjugation yield in vivo and high click release yield. WO2019212356A1
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