| Identification | Back Directory | [Name]
2-AMINO-4-FLUOROPYRIDINE | [CAS]
944401-77-8 | [Synonyms]
4-Fluoropyridin-2-amine
4-FLUORO-2-PYRIDINAMINE
2-PyridinaMine,4-fluoro-
2-Amino-4-fluoropyridine
4-Fluoro-pyridin-2-ylamine
2-Amino-4-Fluoropyridine(WX609167)
2-AMINO-4-FLUOROPYRIDINE ISO 9001：2015 REACH | [EINECS(EC#)]
815-037-5 | [Molecular Formula]
C5H5FN2 | [MDL Number]
MFCD09260906 | [MOL File]
944401-77-8.mol | [Molecular Weight]
112.1 |
| Chemical Properties | Back Directory | [Melting point ]
102 °C | [Boiling point ]
211.5±20.0 °C(Predicted) | [density ]
1.257±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerated. | [form ]
Solid | [pka]
6.42±0.11(Predicted) | [color ]
Pale yellow | [Water Solubility ]
Slightly soluble in water. | [InChI]
InChI=1S/C5H5FN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8) | [InChIKey]
WCCFLOQQACDOAX-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=CC(F)=C1 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Description]
2-Amino-4-fluoropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [Uses]
It is an important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field. | [Synthesis]
General procedure for the synthesis of 2-amino-4-fluoropyridine from 2-amino-4-chloropyridine: 28 g of 2-amino-4-chloropyridine was dissolved in 100 ml of N,N-dimethylformamide, followed by the addition of 46 g of sodium fluoride. The reaction mixture was heated to 140°C and kept reacting for 5 to 8 hours. Upon completion of the reaction, the mixture was cooled to 80 °C and the solvent was subsequently recovered by distillation under reduced pressure. The residue was dissolved in dichloromethane and washed with saturated saline. The organic phase was separated and after evaporation of the solvent, recrystallized from ethanol to give 22 g of white solid 2-amino-4-fluoropyridine in 90% yield. | [References]
[1] Patent: CN108440402, 2018, A. Location in patent: Paragraph 0008; 0020; 0023-0024; 0027-0028; 0031 |
|
|