| Identification | Back Directory | [Name]
H2N-PEG2-Propyne | [CAS]
944561-44-8 | [Synonyms]
944561-44-8
Alkyne-PEG2-NH2
H2N-PEG2-Propyne
HC≡C-CH2-PEG2-NH2
Alkyne-PEG2-amine
Propargyl-PEG2-NH2
Propyne-PEG2-amine
Propargyl-PEG2-amine
2-(2-prop-2-ynoxyethoxy)ethanamine
2-(2-Prop-2-ynyloxy-ethoxy)-ethyla
2-[2-(Propargyloxy)ethoxy]ethylamine
2-[2-(2-Propynyloxy)ethoxy]ethylamine
2-[2-(2-Propynyloxy)ethoxy]ethylamine>
2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanamine
Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]-
2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine
2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine hydrochloride | [Molecular Formula]
C7H13NO2 | [MDL Number]
MFCD19160595 | [MOL File]
944561-44-8.mol | [Molecular Weight]
143.184 |
| Chemical Properties | Back Directory | [Boiling point ]
213.8±20.0 °C(Predicted) | [density ]
0.992±0.06 g/cm3(Predicted) | [refractive index ]
1.4590 to 1.4630 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);698.37(Max Conc. mM) | [form ]
clear liquid | [pka]
8.72±0.10(Predicted) | [color ]
Colorless to Almost colorless | [Appearance]
colorless to yellow liquid |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG2-amine is a crosslinker that is reactive with NHS esters, carbonyls (carboxylic acid, ketone, aldehyde). The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry reaction to form a stable triazole linkage. | [Uses]
2-[2-(2-Propynyloxy)ethoxy]ethylamine is used in preparation of RSV F protein inhibitors conjugated to Fc variants and albumins. | [Synthesis]
The general procedure for the synthesis of 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethylamine from the compound (CAS:1245006-63-6) is as follows: General method: polymer-loaded triphenylphosphine (1.15 eq.) was added to an anhydrous tetrahydrofuran (THF) solution of azide alkynes S3. Subsequently, the reaction mixture was stirred at room temperature for 48 hours. Next, deionized water (1 mL) was added to the flask and the resulting mixture was continued to be stirred at room temperature for 48 hours. Upon completion of the reaction, the mixture was filtered through a bed of diatomaceous earth to collect insoluble solids and washed with ethyl acetate (25 mL). Finally, the combined filtrates were concentrated under reduced pressure to give the target product aminoalkynes 6. | [IC 50]
Non-cleavable Linker; PEGs | [References]
[1] Molecules, 2013, vol. 18, # 9, p. 11639 - 11657
[2] Journal of the American Chemical Society, 2010, vol. 132, # 36, p. 12711 - 12716
[3] Drug Design, Development and Therapy, 2018, vol. 12, p. 987 - 995
[4] Journal of Porphyrins and Phthalocyanines, 2013, vol. 17, # 1-2, p. 104 - 117 |
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