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ChemicalBook--->CAS DataBase List--->98719-20-1

98719-20-1

98719-20-1 Structure

98719-20-1 Structure
IdentificationBack Directory
[Name]

Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl-
[CAS]

98719-20-1
[Synonyms]

Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl-
[Molecular Formula]

C18H24N2O4S
[MOL File]

98719-20-1.mol
[Molecular Weight]

364.46
Chemical PropertiesBack Directory
[Boiling point ]

541.9±60.0 °C(Predicted)
[density ]

1.38±0.1 g/cm3(Predicted)
[pka]

14.04±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

L-654284 is an α2-adrenergic receptor antagonist with significant selectivity. L-654284 competes with the binding of 3H-clonidine and 3H-rauwolscine in vitro and shows Ki values of 0.8 nM and 1.1 nM, respectively. L-654284 can block the protrusion effect of clonidine in isolated vas deferens in rats, with a pA2 value of 9.1. L-654284 exhibits remarkable selectivity for α2 and α1 adrenergic receptors, and exhibits a Ki of 110 nM in inhibiting 3H-prazosin binding. L-654284 can significantly increase the turnover rate of norepinephrine in rat cerebral cortex in vivo, showing α2-adrenergic receptor blocking activity in the central nervous system[1].
[References]

[1] L-654,284 a new potent and selective alpha 2-adrenoceptor antagonist
98719-20-1 suppliers list
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Website: https://www.targetmol.cn/
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