1013648-04-8

基本信息
2,6-二氯-4-甲基苯甲酸甲酯
2,6-Dichloro-4-methylnicotinic acid methyl ester
2,6-Dichloro-4-methylpyridine-3-carboxylic acid methyl ester
3-Pyridinecarboxylic acid, 2,6-dichloro-4-methyl-, methyl ester
物理化學(xué)性質(zhì)
常見問題列表

62774-90-7

74-88-4

1013648-04-8
A)2,6-二氯-4-甲基煙酸甲酯的合成:在100 mL DMF中溶解8.05 g(39.1 mmol)2,6-二氯-4-甲基煙酸[Lamm, G. Ger. Offen. (1977), DE 2538950],隨后加入8.10 g(58.6 mmol)碳酸鉀。在攪拌條件下,緩慢滴加12.16 mL(27.7 g,195.4 mmol)碘甲烷。反應(yīng)混合物在室溫下持續(xù)攪拌6小時。反應(yīng)完成后,將混合物倒入碎冰中,用EtOAc萃取兩次。合并有機相,用水洗滌,硫酸鎂干燥,過濾后蒸發(fā)溶劑,得到8.47 g(產(chǎn)率99%)2,6-二氯-4-甲基煙酸甲酯,為淺黃色固體。質(zhì)譜數(shù)據(jù):219.0(M+,含2Cl)。
參考文獻(xiàn):
[1] Patent: US2009/48238, 2009, A1. Location in patent: Page/Page column 22
[2] Patent: US2009/318467, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: US2012/101079, 2012, A1. Location in patent: Page/Page column 74
[4] Patent: WO2012/52167, 2012, A1. Location in patent: Page/Page column 171-172
[5] Patent: US2017/183342, 2017, A1. Location in patent: Paragraph 0231