105258-93-3

基本信息
N-CBZ-3-氮雜環(huán)丁酮
芐氧羰基氮雜環(huán)丁烷-3-酮
3-氧代吖丁啶-1-羧酸芐酯
N-CBZ-氮雜環(huán)丁烷-3-酮
1-芐氧羰基氮雜環(huán)丁烷-3-酮
1-芐氧羰基-3-酮氮雜環(huán)丁烷
1-CBZ-氮雜環(huán)丁烷-3-酮
1-芐氧羰基-3-氧代氮雜環(huán)丁烷
3-氧代氮雜環(huán)丁烷-1-甲酸芐酯
N-CBZ-3-OXOAZETIDINE
Azetidin-3-one, N-CBZ protected
1-(Benzyloxycarbonyl)azetidin-3-one
3-Oxo-azetidine-1-carboxylic acid benzyl ester
3-oxo-1-azetidinecarboxylic acid (phenylmethyl) ester
1-Azetidinecarboxylic acid, 3-oxo-, phenylMethyl ester
Benzyl 3-oxoazetidine-1-carboxylate, 1-[(Benzyloxy)carbonyl]-3-oxoazetidine
物理化學(xué)性質(zhì)
制備方法

128117-22-6

105258-93-3
以1-芐氧羰基-3-羥基氮雜環(huán)丁烷為原料合成1-芐氧羰基氮雜環(huán)丁烷-3-酮的一般步驟:在室溫條件下,將三苯基甲基-3-羥基氮雜環(huán)丁烷-1-羧酸酯(3.5g,0.0168mol)溶解于二氯甲烷(100mL)中,隨后加入Dess-Martin periodinane(10.7g,0.025mol)。反應(yīng)混合物在室溫下攪拌5小時。反應(yīng)完成后,用1:1比例的飽和碳酸氫鈉水溶液和1M硫代硫酸鈉溶液(200mL)淬滅反應(yīng)?;旌衔镉枚燃淄檩腿?,分離有機層。有機層用無水硫酸鎂干燥,隨后在減壓條件下濃縮,得到3-氧代氮雜環(huán)丁烷-1-羧酸苯基甲酯(3.43g,收率99%),產(chǎn)物為透明無色油狀物,無需進一步純化。產(chǎn)物經(jīng)1H NMR(400MHz,CDCl3)確認:δ 7.39-7.31(m,5H),5.17(s,2H),4.77(s,4H)。質(zhì)譜(EI)分析結(jié)果與C11H11NO3的分子量相符:205(M+)。
參考文獻:
[1] Patent: WO2007/44515, 2007, A1. Location in patent: Page/Page column 165
[2] Patent: WO2008/76415, 2008, A1. Location in patent: Page/Page column 329
[3] Patent: WO2008/124085, 2008, A2. Location in patent: Page/Page column 179
[4] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 33; 34
[5] Patent: WO2013/8002, 2013, A1. Location in patent: Page/Page column 49