1233355-57-1
中文名稱
化合物 T24396
英文名稱
LDN 209929 dihydrochloride
CAS
1233355-57-1
分子式
C17H17ClN2OS
分子量
332.85
MOL 文件
1233355-57-1.mol
1233355-57-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T24396化合物 LDN-209929
LDN-209929 DIHYDROCHLORIDE|||LDN209929 DIHYDROCHLORIDE|||LDN 209929 DIHYDROCHLORIDE
英文別名
LDN-209929LDN209929 2HCl
LDN 209929 2HCl
LDN-209929 2HCl
LDN 209929 dihydrochloride
LDN209929 2HCl,LDN 209929 2HCl
1-Propanamine, 3-[(2-chloro-7-methoxy-9-acridinyl)thio]-
化合物 T24396價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-110320 | 化合物 T24396 LDN-209929 dihydrochloride | 1233355-57-1 | 1 mg | 727元 |
| 2025/02/08 | HY-110320 | 化合物 T24396 LDN-209929 dihydrochloride | 1233355-57-1 | 10 mM * 1 mLin DMSO | 1428元 |
| 2025/02/08 | HY-110320 | 化合物 T24396 LDN-209929 dihydrochloride | 1233355-57-1 | 5 mg | 1600元 |
常見問題列表
生物活性
LDN-209929 dihydrochloride 是一種有效和選擇性的 haspin kinase 抑制劑 (IC50=55 nM)，具有 180 倍的選擇性，比 DYRK2 (IC50=9.9 μM)。LDN-209929 是 LDN-192960 (HY-13455) 的優(yōu)化物。靶點
IC50: 55 nM (haspin kinase)IC50: 9.9 μM (DYRK2)
體外研究
Haspin: Haploid Germ Cell-Specific Nuclear Protein Kinase, is a serine/threonine kinase expressed in a variety of tissues (e.g., testis, bone marrow, thymus, and spleen). Haspin also plays an important role in mitosis, where it phosphorylates histone H3 at Thr-3 (H3T3) in G2/early prophase, becomes maximal during prometaphase/metaphase and then diminishes during anaphase. DYRKs belong to the CMGC family of ePKs and can be further divided into class 1 kinases DYRK1A and 1B, and class 2 kinases DYRK2, 3, and 4. The activity of DYRKs depends upon autophosphorylation of an essential activation loop tyrosine during synthesis.