1289942-66-0

基本信息
3-氟-4-[(甲基氨基)羰基]苯基]-2-甲基丙氨酸
2-(3-氟-4-(甲基氨基甲酰基)苯基氨基)-2-甲基丙酸
N-[3-氟-4-[(甲基氨基)羰基]苯基]-2-甲基丙氨酸
EZLA-M1
Enzalutamide ITS-2
N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]
N-[3-fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methyl-
N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine
2-[3-fluoro-4-(methylcarbamoyl)anilino]-2-methyl-propanoicaci
2-[3-fluoro-4-(methylcarbamoyl)anilino]-2-methyl-propanoic acid
5. N-[3-Fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methylalanine
Alanine, N-[3-fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methyl-
物理化學(xué)性質(zhì)
制備方法

749927-69-3

62-57-7
![N-[3-氟-4-[(甲基氨基)羰基]苯基]-2-甲基丙氨酸](/CAS/20150408/GIF/1289942-66-0.gif)
1289942-66-0
以4-溴-2-氟-N-甲基苯甲酰胺和2-氨基異丁酸為原料合成2-((3-氟-4-(甲基氨基甲?;?苯基)氨基)-2-甲基丙酸的一般步驟如下:將4-溴-2-氟-N-甲基苯甲酰胺(10g,43.1mmol)、2-氨基異丁酸(6.7g,64.7mmol)、碳酸鉀(23.8g,172.4mmol)和脯氨酸(0.7g,4.31mmol)依次加入單頸燒瓶中。隨后,將水(1.8ml,100mmol)溶于DMF(60ml)中,并將此溶液加入燒瓶。在氮?dú)獗Wo(hù)下,向反應(yīng)混合物中加入CuCl(0.45g,4.31mmol),然后將反應(yīng)體系加熱至100℃,持續(xù)攪拌反應(yīng)24小時。反應(yīng)完成后,向反應(yīng)混合物中加入水稀釋,并用二氯甲烷萃取。分離有機(jī)相后,用1mol/L檸檬酸溶液調(diào)節(jié)水相的pH至4,此時會有固體析出。過濾收集固體,并用水和乙醇(體積比100:1)的混合溶液洗滌三次,最終得到9.5g純白色固體產(chǎn)物,收率為87%。
參考文獻(xiàn):
[1] Patent: CN105330560, 2016, A. Location in patent: Paragraph 0023; 0024; 0025; 0026; 0027
[2] Patent: WO2011/106570, 2011, A1. Location in patent: Page/Page column 44
[3] Patent: WO2016/5875, 2016, A1. Location in patent: Page/Page column 15
[4] Patent: CN104016924, 2016, B. Location in patent: Paragraph 0017; 0026-0028