129888-60-4

基本信息
1-BOC-3-[(甲磺?;?氧基]哌啶
3-(甲基磺?;趸?哌啶-1-羧酸叔丁酯
1-Boc-3-methanesulfonyloxy-piper
N-BOC-3-(Methylsulfonyloxy)piperidine
1-Boc-3-methanesulphonyloxypiperidine
tert-Butyl 3-Methylsulfonyloxypiperidin-1-carboxylate
tert-Butyl 3-Methylsulfonyloxypiperidine-1-carboxylate
1-(tert-Butoxycarbonyl)-3-(methanesulfonyloxy)piperidine
tert-Butyl 3-(methanesulfonyloxy)piperidine-1-carboxylate
3-methylsulfonyloxy-1-piperidinecarboxylic acid tert-butyl ester
3-(Methylsulfonyloxy)piperidine-1-carboxylic acid tert-butyl ester
物理化學性質
制備方法

85275-45-2

124-63-0

129888-60-4
步驟1. 在0℃冰浴條件下,向攪拌的3-羥基哌啶-1-羧酸叔丁酯(5g,24.84mmol)和三乙胺(5.027g,6.924mL,49.68mmol)的二氯甲烷(50mL)溶液中緩慢加入甲基磺酰氯(3.130g,2.115mL,27.32mmol)。反應混合物在3小時內逐漸升溫至室溫。反應完成后,用水和1M鹽酸洗滌反應混合物,隨后用硫酸鎂干燥,過濾并真空濃縮,得到3-((甲基磺酰基)氧基)哌啶-1-羧酸叔丁酯,為黃色油狀物(7.9g,定量收率,含少量殘留溶劑)。1H NMR(400.0MHz,CDCl3)δ1.49(s,9H),1.60-1.57(m,1H),2.04-1.79(m,3H),3.08(s,3H),3.38-3.32(m,1H),3.50-3.43(m,1H),3.70-3.60(m,2H)和4.74(br s,1H)ppm。
參考文獻:
[1] Patent: US2013/115310, 2013, A1. Location in patent: Paragraph 0248; 0249
[2] Patent: US2016/168156, 2016, A1. Location in patent: Paragraph 0485; 0486
[3] Carbohydrate Research, 1990, vol. 204, # 1, p. 11 - 25
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4334 - 4343
[5] Patent: US2017/305920, 2017, A1. Location in patent: Paragraph 0151; 0152