132813-14-0
132813-14-0 結(jié)構(gòu)式
基本信息
博蘭色林雜質(zhì)14
2-氯-4-(4-氟苯基)-5,6,7,8,9,10-六氫環(huán)辛烷并吡啶
-氯-4-(4-氟苯基)-5,6,7,8,9,10-六氫環(huán)辛烷并[B]吡啶
2-氯-4-(4-氟苯基)-5,6,7,8,9,10-六氫環(huán)辛烷并[B]吡啶
BlonserinImpurity14
Blonanserin Impurity 14
Blonanserin Intermediate
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10...
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[...
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctapyridine
2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
Cycloocta[b]pyridine, 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-
物理化學(xué)性質(zhì)
常見問題列表
![4-(4-氟苯基)-5,6,7,8,9,10-六氫環(huán)辛烷并[B]吡啶-2(1H)-酮](/CAS/GIF/132812-72-7.gif)
132812-72-7
132813-14-0
以4-(4-氟苯基)-5,6,7,8,9,10-六氫環(huán)辛烷并[B]吡啶-2(1H)-酮為原料合成2-氯-4-(4-氟苯基)-5,6,7,8,9,10-六氫環(huán)辛烷并[b]吡啶的一般步驟：將80.0 g 4-(4-氟苯基)-5,6,7,8,9,10-六氫環(huán)辛烷并[b]吡啶-2(1H)-酮溶解于520 mL二甲基甲酰胺中，冷卻至5℃。在攪拌下，分10次加入36.84 g五氯化磷。加畢，將反應(yīng)體系溫度升至15℃，繼續(xù)反應(yīng)3小時。反應(yīng)完成后，向反應(yīng)混合物中加入520 mL純化水，于10℃下攪拌1小時。使用布氏漏斗（Coors）過濾反應(yīng)液，收集沉淀的晶體，并用300 mL純水洗滌濾餅。將所得晶體于70℃下干燥，得到灰白色的2-氯-4-(4-氟苯基)-5,6,7,8,9,10-六氫環(huán)辛烷并[b]吡啶80.0 g，產(chǎn)率為93.6%。
參考文獻(xiàn)：
[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 4, p. 1055 - 1059
[2] Patent: KR2015/117123, 2015, A. Location in patent: Paragraph 0046; 0047; 0048
[3] Patent: , 2016, . Location in patent: Paragraph 0026; 0027; 0028; 0029
[4] Asian Journal of Chemistry, 2014, vol. 26, # 18, p. 5928 - 5930
[5] Patent: JP2018/43989, 2018, A. Location in patent: Paragraph 0136-0138