194093-42-0
194093-42-0 結(jié)構(gòu)式
基本信息
7-氧代-N-[3(R)-奎寧環(huán)基]-4,7-二氫噻吩并[3,2-B]吡啶-6-甲酰胺鹽酸鹽
Pumosetrag
MKC-733 >=98% (HPLC)
Pumosetrag hydrochloride
PuMosetrag hydrochloride MKC-733
7-Oxo-N-[3(R)-quinuclidinyl]-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide hydrochloride
N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride
物理化學性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-19650 | 7-氧代-N-[3(R)-奎寧環(huán)基]-4,7-二氫噻吩并[3,2-B]吡啶-6-甲酰胺鹽酸鹽 Pumosetrag Hydrochloride | 194093-42-0 | 1 mg | 500元 |
| 2025/02/08 | HY-19650 | 7-氧代-N-[3(R)-奎寧環(huán)基]-4,7-二氫噻吩并[3,2-B]吡啶-6-甲酰胺鹽酸鹽 Pumosetrag Hydrochloride | 194093-42-0 | 5mg | 1100元 |
| 2025/02/08 | HY-19650 | 7-氧代-N-[3(R)-奎寧環(huán)基]-4,7-二氫噻吩并[3,2-B]吡啶-6-甲酰胺鹽酸鹽 Pumosetrag Hydrochloride | 194093-42-0 | 10mM * 1mLin DMSO | 1210元 |
常見問題列表
|
5-HT 3 Receptor
|
Pumosetrag displays both regional and species specificities. Pumosetrag has a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it has similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Pumosetrag shows little to no response in the regions of the mouse intestine. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors. Pumosetrag delays liquid gastric emptying in association with relaxation of the proximal stomach, stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit.