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216167-82-7

中文名稱 AGI 1067
英文名稱 4-[4-[2-(4-hydroxy-3,5-ditert-butyl-phenyl)sulfanylpropan-2-ylsulfanyl]-2,6-ditert-butyl-phenoxy]-4-oxo-butanoic acid
CAS 216167-82-7
分子式 C35H52O5S2
分子量 616.91
MOL 文件 216167-82-7.mol
更新日期 2025/05/22 09:46:39
216167-82-7 結(jié)構(gòu)式 216167-82-7 結(jié)構(gòu)式

基本信息

中文別名
化合物SUCCINOBUCOL
英文別名
AGI 1067
AGZ-1067
SUCCINOBUCOL
SUCCINOBUCOL, >98%
Probucol Monosuccinate
Succinobucol(AGI 1067)
Probucol monosuccinate, >98%
AGZ1067. Probucol monosuccinae
AGI-1067
PROBUCOL MONOSUCCINATE
SUCCINOBUCOL
AGI-1067
AGZ-1067
AGI1067
AGZ1067. PROBUCOL MONOSUCCINAE

物理化學(xué)性質(zhì)

熔點(diǎn)139 - 142°C
沸點(diǎn)659.5±55.0 °C(Predicted)
密度1.13±0.1 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度可溶于氯仿(少許)、甲醇(少許)
酸度系數(shù)(pKa)4.27±0.17(Predicted)
形態(tài)固體
顏色白色至淺黃色

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338
AGI 1067價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/05/22HY-14937AGI 1067
Succinobucol
216167-82-75mg355元
2025/05/22HY-14937AGI 1067
Succinobucol
216167-82-710mM * 1mLin DMSO482元
2025/05/22HY-14937AGI 1067
Succinobucol
216167-82-710mg550元

常見問題列表

生物活性
AGI-1067是一種新型的、酚類的細(xì)胞內(nèi)外抗氧化劑,可抑制一系列參與動(dòng)脈粥樣硬化的促炎性基因的表達(dá)。
體外研究

Succinobucol (10, 50, 100 μM) causes a dose-dependent reduction in collagen-induced platelet aggregation in rabbit whole blood. Succinobucol also causes a significant reduction in whole blood aggregation in response to ADP. Succinobucol (10, 100 μM) significantly lowers the relaxation to X/XO. Succinobucol significantly prevents 3-NP-induced loss of SH-SY5Y cell viability, generation of reactive oxygen species, and decrease of ΔΨm. Succinobucol does not protect against 3-NP-induced inhibition of mitochondrial complex II activity, pointing to the mitigation of secondary events resultant from mitochondrial complex II inhibition. Succinobucol significantly increases (50 %) the levels of GSH in SH-SY5Y cells, which is paralleled by significant increases in glutamate cysteine ligase messenger RNA (mRNA) expression and activity. Succinobucol effectively exhibits superior inhibitory effects on cell migration and invasion activities, VCAM-1 expression and cell-cell binding of RAW 264.7 to 4T1 cells. Succinobucol also shows inhibitory effect on VCAM-1 expression in 4T1 cells and cell-cell binding of RAW 264.7 to 4T1 cancer cells.

體內(nèi)研究

Succinobucol (50, 100, and 150 mg/kg, i.v.) has no significant effect on either heart rate or MAP, but the blood removed 15 minutes after the final injection of succinobucol shows significantly less aggregation in response to collagen at both 5 μg/mL and 20 μg/mL in rats. Succinobucol (40 mg/kg) by tail injection significantly reduces the average number of metastatic nodules in lung metastatic breast cancer mice.

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