2321366-46-3
中文名稱(chēng)
NW-PROPYL-L-ARGININE HYDROCHLORIDE
英文名稱(chēng)
Nw-Propyl-L-arginine hydrochloride
CAS
2321366-46-3
分子式
C9H21ClN4O2
分子量
252.74
MOL 文件
2321366-46-3.mol
更新日期
2025/04/22 21:32:52
2321366-46-3 結(jié)構(gòu)式
基本信息
英文別名
Nw-Propyl-L-arginine hydrochlorideNωPropylLarginine hydrochloride,Nω Propyl L arginine hydrochloride
常見(jiàn)問(wèn)題列表
生物活性
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride 是一種高效、競(jìng)爭(zhēng)性、高選擇性的神經(jīng)型一氧化氮合酶 (nNOS) 抑制劑，Ki為 57 nM。Nω-Propyl-L-arginine hydrochloride 對(duì) nNOS 的選擇性是內(nèi)皮型一氧化氮合酶 (eNOS) 的 149 倍。體內(nèi)研究
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity.
| Animal Model: | Male NMRI mice (30-40 g) (phencyclidine-induced stimulation) |
| Dosage: | 20 mg/kg |
| Administration: | I.p. |
| Result: | Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity. |