234108-73-7

基本信息
2-氯吡啶-4-氨基甲酸叔丁酯
N-BOC-2-氯-4-吡啶胺
4-(BOC-氨基)-2-氯吡啶
2-氨基吡啶-4-氨基甲酸叔丁酯
4-(N-叔丁氧羰基氨基)-2-氯吡啶
N-Boc-2-chloro-4-pyridinamine
4-(Boc-amino)-2-chloropyridine
N-BOC PROTECTED 4-AMINO-2-CHLOROPYRIDINE
tert-Butyl 2-chloropyridin-4-ylcarbamate
4-Amino-2-chloropyridine, 4-BOC protected
ert-butylN-(2-chloropyridin-4-yl)carbamate
tert-butyl N-(2-chloropyridin-4-yl)carbamate
4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98
4-Amino-2-chloropyridine, N-BOC protected 98%
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法

14432-12-3

24424-99-5

234108-73-7
以2-氯-4-氨基吡啶和二碳酸二叔丁酯為原料合成2-氯吡啶-4-氨基甲酸叔丁酯的一般步驟:在95 mg 4-二甲氨基吡啶(DMAP)存在下,將1.69 g(7.78 mmol,1當(dāng)量)二碳酸二叔丁酯溶于50 mL二氯甲烷中,緩慢加入至含有1 g(7.78 mmol,1當(dāng)量)2-氯-4-氨基吡啶和1.19 mL(1.19 mmol,1.1當(dāng)量)三乙胺的30 mL二氯甲烷溶液中。反應(yīng)混合物在室溫下攪拌過(guò)夜。反應(yīng)完成后,加入100 mL水淬滅反應(yīng),隨后用二氯甲烷萃取。合并有機(jī)相,用無(wú)水硫酸鈉干燥。減壓蒸除溶劑后,殘余物通過(guò)硅膠柱色譜純化(洗脫劑比例從70/30至50/50的庚烷/乙酸乙酯梯度變化)。所得油狀物經(jīng)戊烷結(jié)晶,得到1.40 g 2-氯吡啶-4-氨基甲酸叔丁酯,產(chǎn)率為80%。
參考文獻(xiàn):
[1] Patent: WO2006/53791, 2006, A2. Location in patent: Page/Page column 49-50
[2] Tetrahedron Letters, 2014, vol. 55, # 49, p. 6734 - 6737
[3] Patent: WO2005/33072, 2005, A2. Location in patent: Page/Page column 26
[4] Patent: WO2004/43926, 2004, A1. Location in patent: Page 161
[5] Patent: US2004/102450, 2004, A1. Location in patent: Page/Page column 100