3913-19-7

基本信息
2-Chloro-4-Methyl-6-broMoquinoline
6-BROMO-2-CHLORO-4-METHYLQUINOLINE
Quinoline, 6-bromo-2-chloro-4-methyl-
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表

89446-19-5

3913-19-7
以6-溴-4-甲基-2(1H)-喹啉酮為原料合成6-溴-2-氯-4-甲基喹啉的一般步驟:向2.7g(11.34mmol)的6-溴-4-甲基-1H-喹啉-2-酮(實(shí)施例1b)中加入25mL磷酰氯,將反應(yīng)混合物回流2小時(shí)。反應(yīng)完成后,冷卻至室溫,將混合物緩慢倒入250mL的10%氨水溶液中,析出沉淀。過(guò)濾收集沉淀,用水洗滌,并在30℃的循環(huán)空氣干燥器中干燥。得到產(chǎn)物2.7g,產(chǎn)率為93%。產(chǎn)物表征:C10H7BrClN(M = 256.526);計(jì)算分子離子峰(M + H)+:256/258/260(BrCl);實(shí)測(cè)分子離子峰(M + H)+:256/258/260(BrCl);Rf值:0.95(硅膠,二氯甲烷/甲醇 9:1)。
參考文獻(xiàn):
[1] Journal of Medicinal Chemistry, 1989, vol. 32, # 8, p. 1936 - 1942
[2] Synthesis, 2011, # 6, p. 934 - 942
[3] Patent: US2005/234101, 2005, A1. Location in patent: Page/Page column 14
[4] Patent: WO2005/103002, 2005, A2. Location in patent: Page/Page column 44-45
[5] Patent: US2005/267115, 2005, A1. Location in patent: Page/Page column 33