69879-22-7

基本信息
2-氨基-5-醛基吡啶
6-氨基吡啶-3-甲醛
LY2835219中間體7
6-甲基-2-吡嗪甲酸...
2-氨基-5-醛基吡啶鹽酸鹽
6-Aminonicotinaldehyde
2-aMino-5-forMylpyridine
6-Amino-pyridine-3-carbaldehyde
6-Aminopyridine-3-carboxaldehyde
6-aMino-3-Pyridinecarboxaldehyde
3-Pyridinecarboxaldehyde, 6-amino-
6-aMinonicotinaldehyde hydrochloride
6-aMinonicotinaldehyde 6-aMinonicotinaldehyde hydrochloride
物理化學(xué)性質(zhì)
常見問題列表

4214-73-7

69879-22-7
以2-氨基-5-氰基吡啶為原料合成2-氨基-5-醛基吡啶的一般步驟:在0℃下,向2-氨基-5-氰基吡啶(10g,83.95mmol,1當(dāng)量)的四氫呋喃(THF,150mL)溶液中緩慢加入氫化鋁鋰(LAH,6.37g,167.90mmol,2當(dāng)量)。反應(yīng)混合物在0℃下持續(xù)攪拌1.5小時(shí)。反應(yīng)完成后,在0℃下通過加入飽和硫酸鈉溶液淬滅反應(yīng),隨后加入水(100mL)。用乙酸乙酯(100mL×3)萃取反應(yīng)混合物。合并有機(jī)層,用飽和鹽水(30mL×1)洗滌,無水硫酸鈉干燥,過濾后減壓濃縮,得到目標(biāo)產(chǎn)物2-氨基-5-醛基吡啶(7.50g,61.42mmol,收率73.16%),為黃色油狀物。LCMS(ESI)分析結(jié)果:m/z [M + H]+理論值C6H6N2O為123;實(shí)測值為123;保留時(shí)間(RT)= 0.099分鐘。
參考文獻(xiàn):
[1] Patent: WO2018/209132, 2018, A1. Location in patent: Paragraph 0458; 0489
[2] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 292 - 300
[3] Patent: US2009/143420, 2009, A1. Location in patent: Page/Page column 7
[4] Patent: EP1724263, 2006, A1. Location in patent: Page/Page column 55
[5] Patent: EP3305785, 2018, A1. Location in patent: Paragraph 0177; 0178