3-氧代-5BETA-膽酸
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- CAS號(hào):
- 1553-56-6
- 英文名:
- 3-Oxo-5beta-cholanoic Acid
- 英文別名:
- 3-oxocholanicacid;3-KETOCHOLANIC ACID;3-oxolithocholicacid;3-ketolithocholicacid;3-Oxo-5β-cholanic acid;5β-CHOLANIC acid-3-ONE;3-oxocholan-24-oic acid;5-B-CHOLANIC ACID-3-ONE;5β-Cholanic acid-3-one;3-Oxo-5β-cholanoic Acid
- 中文名:
- 3-氧代-5BETA-膽酸
- 中文別名:
- -膽烷酸;脫氫石膽酸;3-氧代-5&Β;3-氧-5Β-膽酸;熊去氧膽酸雜質(zhì)60;3-酮-5B-膽烷酸;化合物 T13502;3-氧代-5Β-膽酸;3-氧代-5Β-膽烷酸;3-氧代-5&BETA
- CBNumber:
- CB0675020
- 分子式:
- C24H38O3
- 分子量:
- 374.56
- MOL File:
- 1553-56-6.mol
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3-氧代-5BETA-膽酸化學(xué)性質(zhì)
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熔點(diǎn):
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140-141 °C
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沸點(diǎn):
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509.3±23.0 °C(Predicted)
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密度:
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1.069±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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Refrigerator
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溶解度:
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Chloroform (Slightly), Methanol (Slightly)
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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4.76±0.10(Predicted)
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顏色:
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White to Pale Yellow
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CAS 數(shù)據(jù)庫:
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1553-56-6
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3-氧代-5BETA-膽酸性質(zhì)、用途與生產(chǎn)工藝
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid)，膽汁酸代謝產(chǎn)物，通過直接與關(guān)鍵轉(zhuǎn)錄因子RORγt (Kd=1.13 μM) 結(jié)合抑制 TH17 細(xì)胞分化。
Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity.
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells.
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Animal Model:
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B6 Jax mice (with a faecal slurry containing SFB)
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Dosage:
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0.3% (w/w)
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Administration:
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Gavaged; for 1 week
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Result:
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Significantly reduced the percentage of ileal TH17 cells.
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3-氧代-5BETA-膽酸
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2025/05/22 | HY-125801 | 3-氧代-5BETA-膽酸
3-Oxo-5β-cholanoic acid | 1553-56-6 | 1 mg | 156元 |
| 2025/05/22 | HY-125801 | -膽烷酸
3-Oxo-5β-cholanoic acid | 1553-56-6 | 10mM * 1mLin DMSO | 257元 |
1553-56-6, 3-氧代-5BETA-膽酸 相關(guān)搜索:
- 化學(xué)試劑
- 醫(yī)用原料
- 雜質(zhì)對(duì)照品
- 抑制劑
- 藥靶配體
- 3-氧代-5Β-膽烷酸,10 MM DMSO 溶液
- 3-氧代-5Β-膽烷酸標(biāo)準(zhǔn)品
- (R)-4-((5R,8R,9S,10S,13R,14S,17R)-10,13--二甲基-3-氧代十六氫-1H-環(huán)戊并[A]菲17-基)戊酸
- 熊去氧膽酸雜質(zhì)60
- 3-氧-5Β-膽酸
- 3-酮-5B-膽烷酸(脫氫石膽酸)
- 3-酮-5B-膽烷酸
- 化合物 T13502
- 3-氧代-5Β-膽酸
- 3-惡唑烷-24-油酸
- 3-氧代-5BETA-膽酸
- 脫氫石膽酸
- 3-氧代-5Β-膽烷酸
- 3-氧代-5&BETA
- 3-氧代-5&Β
- -膽烷酸
- 1553-56-6
- 3-Oxo-5β-cholanoic Acid, CAS 1553-56-6
- 3-Keto-5beta-cholanic acid, 98%
- 3-Oxo-5β-cholanoic acid, 10 mM in DMSO
- Ursodeoxycholic acid impurity 60
- (R)-4-((5R,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
- Cholan-24-oic acid, 3-oxo-, (5β)-
- cell,factor,RAR-related orphan receptor,3 Oxo 5β cholanoic acid,TH17,RORγt,differentiation,acid,bile,Inhibitor,responses,transcription,inhibit,ROR,3Oxo5βcholanoic acid,immune,3-oxoLCA
- 5β-CHOLANIC acid-3-ONE
- 3-Oxo-5beta-cholanoic Acid
- DEHYDROLITHOCHOLIC ACID
- 3-oxo-5beta-cholanic acid
- 3-Keto-5β-cholanic acid
- 3-Oxo-5β-cholanoic Acid
- 3-Oxo-5β-cholanic acid
- 3-Oxo-5β-cholan-24-oic acid
- 5β-Cholanic acid-3-one
- 3-Keto-5β-cholanic acid, Dehydrolithocholic acid
- 3-oxocholan-24-oic acid
- 5-B-CHOLANIC ACID-3-ONE
- 3-oxolithocholicacid
- 3-oxocholanicacid
- 3-oxo-5-beta-cholan-24-oicacid
- 3-oxo-5-beta-cholan-24-oicaci
- 3-ketolithocholicacid
- (5-beta)-cholan-24-oicaci
- 3-KETO-5BETA-CHOLANIC ACID
- 3-KETOCHOLANIC ACID
- 5BETA-CHOLANIC ACID-3-ONE