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ChemicalBook >> CAS DataBase List >>SR3335

SR3335

CAS No.
293753-05-6
Chemical Name:
SR3335
Synonyms
ML-176;SR3335;SR3335;ML176;ML-176;SR-3335;SR3335, 10 mM in DMSO;ML-176;SR 3335;SR-3335;ML176;ML 176;SR3335;ML-176;SR 3335;SR-3335;ML176;ML 176;SR 3335 (This product is only available in Japan.);N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]thiophene-2-sulfonamide;N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide
CBNumber:
CB12628427
Molecular Formula:
C13H9F6NO3S2
Molecular Weight:
405.3358792
MDL Number:
MFCD02724814
MOL File:
293753-05-6.mol
MSDS File:
SDS
Last updated:2025-04-28 21:36:36

SR3335 Properties

storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility insoluble in H2O; ≥87.4 mg/mL in EtOH; ≥88.8 mg/mL in DMSO
form solid
color White to off-white
UNSPSC Code 12352200
NACRES NA.77

SR3335 price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2820 SR3335 ≥98% (HPLC) 293753-05-6 5MG $94.2 2024-03-01 Buy
Sigma-Aldrich SML2820 SR3335 ≥98% (HPLC) 293753-05-6 25MG $381 2024-03-01 Buy
Cayman Chemical 12072 SR 3335 ≥95% 293753-05-6 1mg $32 2024-03-01 Buy
Cayman Chemical 12072 SR 3335 ≥95% 293753-05-6 5mg $106 2024-03-01 Buy
Cayman Chemical 12072 SR 3335 ≥95% 293753-05-6 10mg $186 2024-03-01 Buy
Product number Packaging Price Buy
SML2820 5MG $94.2 Buy
SML2820 25MG $381 Buy
12072 1mg $32 Buy
12072 5mg $106 Buy
12072 10mg $186 Buy

SR3335 Chemical Properties,Uses,Production

Description

The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM). It is without effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor α. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis.

Uses

SR3335 (ML 176) is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220 nM[1][2].

Definition

ChEBI: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-thiophenesulfonamide is a sulfonamide.

in vivo

SR3335 displays reasonable exposure following an i.p. injection into mice. The ability of SR3335 is assessed to suppress gluconeogenesis using a diet-induced obesity (DIO) mouse model where the mice where treated with 15 mg/kg b.i.d., i.p. for 6-days followed by a pyruvate tolerance test. SR3335 treated mice displays lower plasma glucose levels following the pyruvate challenge consistent with suppression of gluconeogenesis. Importantly, mice treated with SR3335 displayed no difference in body weight or food intake after 7-days of treatment with SR3335[1].
SR3335 (15 mg/kg/day; ip for 7 days) reduces rhinovirus (RV)-induced lung ILC2s in immature mice (RV infection of 6-day-old BALB/c mice)[3].

target

RORα

References

[1] Kumar N, et al. Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist. ACS Chem Biol. 2011 Mar 18;6(3):218-22. DOI:10.1021/cb1002762
[2] Rajput C, et al. RORα-dependent type 2 innate lymphoid cells are required and sufficient for mucous metaplasia in immature mice. Am J Physiol Lung Cell Mol Physiol. 2017;312(6):L983-L993. DOI:10.1152/ajplung.00368.2016

16629-19-9
722-92-9
293753-05-6
Synthesis of SR3335 from 2-Thiophenesulfonyl chloride and 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE

SR3335 Preparation Products And Raw materials

Global( 86)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29807 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32281 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38665 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58

View Lastest Price from SR3335 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SR3335 pictures 2025-04-27 SR3335
293753-05-6
 US $31.00-128.00 / mg 99.77% 10g TargetMol Chemicals Inc.
SR3335 pictures 2019-12-23 SR3335
293753-05-6
 US $9.80 / KG 1g 99% 100kg Career Henan Chemical Co
  • SR3335 pictures
  • SR3335
    293753-05-6
  • US $31.00-128.00 / mg
  • 99.77%
  • TargetMol Chemicals Inc.
  • SR3335 pictures
  • SR3335
    293753-05-6
  • US $9.80 / KG
  • 99%
  • Career Henan Chemical Co

SR3335 Spectrum

SR3335 SR3335,Thiophene-2-sulfonic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-aMide ML-176 N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide hiophene-2-sulfonic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-aMide ML-176;SR-3335 SR3335;ML-176;SR 3335;SR-3335;ML176;ML 176 SR3335;ML176 SR 3335 (This product is only available in Japan.) Thiophene-2-sulfonic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-aMide ML-176;SR 3335;SR-3335;ML176;ML 176 2-Thiophenesulfonamide, N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]- N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]thiophene-2-sulfonamide SR3335, 10 mM in DMSO 293753-05-6 C13H9F6NO3S2