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ChemicalBook >> CAS DataBase List >>PD 134922

PD 134922

CAS No.
150351-30-7
Chemical Name:
PD 134922
Synonyms
PD 134922;L-Norvalinamide, N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-[4-[(butylamino)carbonyl]-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]-4,5-didehydro-, [1S-(1R*,2R*,4R*)]- (9CI)
CBNumber:
CB31401029
Molecular Formula:
C37H61N5O7S
Molecular Weight:
719.97
MDL Number:
MOL File:
150351-30-7.mol
Last updated:2025-04-18 09:52:04

PD 134922 Properties

Density 1.19±0.1 g/cm3(Predicted)
pka 10.97±0.20(Predicted)

PD 134922 Chemical Properties,Uses,Production

Description

PD 134922 is a novel HIV-1 protease inhibitors identified by rational selection.The human immunodeficiency virus (HIV-1), associated with the AIDS (acquired immunodeficiency syndrome) epidemic, encodes an aspartyl protease that is essential for polyprotein processing in the virus (Navia et al., 1989). It has been demonstrated that inactivation of the protease either catalytically or by an inhibitor prevents infectious virion formation (Kohl et al., 1988; Darke et al., 1989). The acquired knowledge of key molecular interactions occurring between inhibitors and aspartyl proteases, as well as the structural similarities between HIV-1 protease and human renin was used to rationally select candidates for HIV-1 screening from the pool of analogs designed as renin inhibitors. A minimal number of chosen compounds were tested in an HIV-1 protease assay system. Two structurally novel peptides emerged as potent enzymatic protease inhibitors.

Uses

PD 134922 is a potent renin and HIV-1 protease inhibitor with an IC50 of 15 nM against HIV-1 protease[1].

References

[1] Humblet CC, et al. Characterization of two structurally novel HIV-1 protease inhibitors identified by rational selection. Antiviral Res. 1993 May;21(1):73-84. DOI:10.1016/0166-3542(93)90068-t

PD 134922 Preparation Products And Raw materials

Raw materials

Preparation Products

PD 134922 Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+17819995354 marketing@targetmol.com United States 32281 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20622 58
PD 134922 L-Norvalinamide, N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-[4-[(butylamino)carbonyl]-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]-4,5-didehydro-, [1S-(1R*,2R*,4R*)]- (9CI) 150351-30-7