ABT-639 (hydrochloride)
- CAS No.
- 1235560-31-2
- Chemical Name:
- ABT-639 (hydrochloride)
- Synonyms
- ABT-639 (hydrochloride)
- CBNumber:
- CB53175520
- Molecular Formula:
- C20H21Cl2F2N3O3S
- Molecular Weight:
- 492.36
- MDL Number:
- MFCD31382140
- MOL File:
- 1235560-31-2.mol
storage temp. | Store at -20°C |
---|---|
solubility | Soluble in DMSO |
FDA UNII | PNZ74XN2EM |
ABT-639 (hydrochloride) Chemical Properties,Uses,Production
Uses
ABT-639 Hydrochloride is used for the optimization of ADME properties for sulfonamides leading to the discovery of a T-type calcium channel blocker, ABT639.
in vivo
ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50=2 μM) and attenuates low voltage-activated (LVA) currents in rat DRG neurons (IC50=8 μM). ABT-639 is significantly less active at other Ca2+ channels (e.g. Cav1.2 and Cav2.2) (IC50>30 mM). ABT-639 has high oral bioavailability (%F=73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents. Following oral administration ABT-639 produces dose-dependent antinociception in a rat model of knee joint pain (ED50=2 mg/kg, p.o.). ABT-639 (10-100 mg/kg, p.o.) also increases tactile allodynia thresholds in multiple models of neuropathic pain (e.g. spinal nerve ligation, CCI, and vincristine-induced, and capsaicin secondary hypersensitivity). ABT-639 does not attenuate hyperalgesia in inflammatory pain models induced by complete Freund’s adjuvant or carrageenan. At higher doses (e.g. 100-300 mg/kg) ABT-639 does not significantly alter hemodynamic or psychomotor function. The antinociceptive profile of ABT-639 provides novel insights into the role of peripheral T-type (Cav3.2) channels in chronic pain states[1].
IC 50
T-type calcium channel
ABT-639 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
ABT-639 (hydrochloride) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19903 | 58 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44813 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24891 | 58 |
Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 6215 | 58 |
United States Biological | -- | sales@advtechind.com | United States | 6075 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
BOC Sciences | 65 |
Energy Chemical | 58 |
TargetMol Chemicals Inc. | 58 |
Biosynth Biological Technology (Suzhou) Co Ltd | 58 |
Adooq Bioscience LLC | 58 |
United States Biological | 58 |
View Lastest Price from ABT-639 (hydrochloride) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2025-04-27 | ABT-639 hydrochloride
1235560-31-2
|
US $1980.00-2500.00 / mg | 10g | TargetMol Chemicals Inc. |
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- ABT-639 hydrochloride
1235560-31-2
- US $1980.00-2500.00 / mg
- TargetMol Chemicals Inc.