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ChemicalBook >> CAS DataBase List >>ABT-639 (hydrochloride)

ABT-639 (hydrochloride)

CAS No.
1235560-31-2
Chemical Name:
ABT-639 (hydrochloride)
Synonyms
ABT-639 (hydrochloride)
CBNumber:
CB53175520
Molecular Formula:
C20H21Cl2F2N3O3S
Molecular Weight:
492.36
MDL Number:
MFCD31382140
MOL File:
1235560-31-2.mol
Last updated:2025-04-28 21:36:36

ABT-639 (hydrochloride) Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
FDA UNII PNZ74XN2EM

ABT-639 (hydrochloride) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A112510 ABT-639Hydrochloride 1235560-31-2 5mg $165 2021-12-16 Buy
Product number Packaging Price Buy
A112510 5mg $165 Buy

ABT-639 (hydrochloride) Chemical Properties,Uses,Production

Uses

ABT-639 Hydrochloride is used for the optimization of ADME properties for sulfonamides leading to the discovery of a T-type calcium channel blocker, ABT639.

in vivo

ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50=2 μM) and attenuates low voltage-activated (LVA) currents in rat DRG neurons (IC50=8 μM). ABT-639 is significantly less active at other Ca2+ channels (e.g. Cav1.2 and Cav2.2) (IC50>30 mM). ABT-639 has high oral bioavailability (%F=73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents. Following oral administration ABT-639 produces dose-dependent antinociception in a rat model of knee joint pain (ED50=2 mg/kg, p.o.). ABT-639 (10-100 mg/kg, p.o.) also increases tactile allodynia thresholds in multiple models of neuropathic pain (e.g. spinal nerve ligation, CCI, and vincristine-induced, and capsaicin secondary hypersensitivity). ABT-639 does not attenuate hyperalgesia in inflammatory pain models induced by complete Freund’s adjuvant or carrageenan. At higher doses (e.g. 100-300 mg/kg) ABT-639 does not significantly alter hemodynamic or psychomotor function. The antinociceptive profile of ABT-639 provides novel insights into the role of peripheral T-type (Cav3.2) channels in chronic pain states[1].

IC 50

T-type calcium channel

ABT-639 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

ABT-639 (hydrochloride) Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+17819995354 marketing@targetmol.com United States 19903 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44813 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24891 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 6051 58
Adooq Bioscience LLC 400-025-6535 sales@adooq.cn China 6215 58
United States Biological -- sales@advtechind.com United States 6075 58

View Lastest Price from ABT-639 (hydrochloride) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ABT-639 hydrochloride pictures 2025-04-27 ABT-639 hydrochloride
1235560-31-2
US $1980.00-2500.00 / mg 10g TargetMol Chemicals Inc.
ABT-639 (hydrochloride) 1235560-31-2