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ChemicalBook >> CAS DataBase List >>3-(3,5-dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid

3-(3,5-dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid

CAS No.
2118899-51-5
Chemical Name:
3-(3,5-dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid
Synonyms
ITB-102;KP-2955;taragarestrant;3-(3,5-dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid;2-Propenoic acid, 3-[3,5-dichloro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-, (2E)-
CBNumber:
CB55849173
Molecular Formula:
C25H25Cl2FN2O2
Molecular Weight:
475.38
MDL Number:
MOL File:
2118899-51-5.mol
Last updated:2025-04-28 21:36:36

3-(3,5-dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid Properties

Boiling point 601.6±55.0 °C(Predicted)
Density 1.322±0.06 g/cm3(Predicted)
pka 4.05±0.10(Predicted)
FDA UNII KD4HIM135V

3-(3,5-dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid Chemical Properties,Uses,Production

Uses

Taragarestrant (D-0502) is a potent, orally active and selective estrogen receptor degrader (SERD). Taragarestrant shows potent activity in various ER+ breast cancer cell lines and xenograft models[1][2].

in vivo

Taragarestrant (D-0502) exhibits superior PK profiles suitable for clinical development[1].

References

[1] Lin WY, et, al. Abstract 5776: Pharmacologic and PK/PD study of D-0502: An orally bioavailable SERD with potent antitumor activity in ER-positive breast cancer cell lines and xenograft models. 2018 Jul 1;78(13):5776.
[2] WHO Drug Information. International Nonproprietary Names for Pharmaceutical

3-(3,5-dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

3-(3,5-dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19903 58
Kaixin Chemical (Hong Kong) Limited 010-88886666-01 13112345678 loyson@tcypharm.com China 596 55
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20614 58

View Lastest Price from 3-(3,5-dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Taragarestrant pictures 2025-04-28 Taragarestrant
2118899-51-5
 US $3520.00-2785.00 / mg 10g TargetMol Chemicals Inc.
  • Taragarestrant pictures
  • Taragarestrant
    2118899-51-5
  • US $3520.00-2785.00 / mg
  • TargetMol Chemicals Inc.
3-(3,5-dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid 2-Propenoic acid, 3-[3,5-dichloro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-, (2E)- ITB-102 taragarestrant KP-2955 2118899-51-5 C25H25Cl2FN2O2