Punicic acid
- CAS No.
- 544-72-9
- Chemical Name:
- Punicic acid
- Synonyms
- Trichosanic acid;9(Z),11(E),13(Z)-OCTADECATRIENOIC ACID;punicicaci;PUNICIC ACID;Trichosanic acid【C18】;(9Z,11E,13Z)-9,11,13-Octadecatrienoic acid;(9Z,11E,13Z)-Octadeca-9,11,13-trienoic acid;9,11,13-Octadecatrienoic acid, (9Z,11E,13Z)-
- CBNumber:
- CB8682750
- Molecular Formula:
- C18H30O2
- Molecular Weight:
- 278.43
- MDL Number:
- MFCD05864026
- MOL File:
- 544-72-9.mol
| Melting point | 62°C |
|---|---|
| Boiling point | 361.24°C (rough estimate) |
| Density | 0.9027 |
| refractive index | 1.5114 |
| solubility | DMF: 30 mg/mL; DMSO: 10 mg/mL; Ethanol: 20 mg/mL |
| form | Liquid |
| pka | 4.78±0.10(Predicted) |
| color | Colorless to light yellow |
| FDA UNII |
3,4-BIS(BENZYLOXY)BENZALDEHYDE (F36FJ659RX) PUNICIC ACID (VFQ03H211O) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS08 |
|---|---|
| Signal word | Danger |
Punicic acid price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26057 | 9(Z),11(E),13(Z)-Octadecatrienoic Acid ≥98% | 544-72-9 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 26057 | 9(Z),11(E),13(Z)-Octadecatrienoic Acid ≥98% | 544-72-9 | 5mg | $249 | 2024-03-01 | Buy |
| Cayman Chemical | 26057 | 9(Z),11(E),13(Z)-Octadecatrienoic Acid ≥98% | 544-72-9 | 10mg | $437 | 2024-03-01 | Buy |
| AK Scientific | 8579CN | Punicicacid | 544-72-9 | 1mg | $160 | 2021-12-16 | Buy |
Punicic acid Chemical Properties,Uses,Production
Uses
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways[1][2][3][4].
Definition
ChEBI: A 9,11,13-octadecatrienoic acid having its double bonds in cis, trans and cis configurations, respectively. It has been isolated from pomegranate (Punica granatum).
in vivo
Punicic acid (400 μg, i.g.; once daily for ten days) reduces significantly the TNBS-induced colonic damage in male Wistar rats by demonstrating mild inflammatory infiltration accompanied by punctate mucosal erosions[2].
| Animal Model: | TNBS-induced Colitis male Wistar rat[1] |
| Dosage: | 400 μg |
| Administration: | i.g. |
| Result: | Reduced the hyperactivation of neutrophils in the colon of TNBS-treated rats and inhibited the release of MPO and ROS by neutrophils, thereby reducing lipid peroxidation and tissue damage. |
References
[1] Shabbir MA, et al. Punicic acid: A striking health substance to combat metabolic syndromes in humans. Lipids Health Dis. 2017;16(1):99. DOI:10.1186/s12944-017-0489-3
[2] Boussetta T, et al. Punicic acid a conjugated linolenic acid inhibits TNFα-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats[J]. PloS one, 2009, 4(7): e6458. DOI:10.1371/journal.pone.0006458
[3] Guerra-Vázquez, et al. Punicic acid and its role in the prevention of neurological disorders: A review. Foods 11.3 (2022): 252. DOI:10.3390/foods11030252
[4] Grossmann, et al. Punicic acid is an ω-5 fatty acid capable of inhibiting breast cancer proliferation. International journal of oncology 36.2 (2010): 421-426. PMID:20043077
Punicic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Punicic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 13184 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| Shandong Believe Chemical PTE.LTD | +86-18553607090 +8618553607090 | 1093908296@qq.com | China | 1664 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42957 | 64 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 3004654993@qq.com | China | 8916 | 60 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 9522 | 58 |