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ChemicalBook--->CAS DataBase List--->2703051-80-1

2703051-80-1

2703051-80-1 Structure

2703051-80-1 Structure
IdentificationBack Directory
[Name]

L-Lysine, N6-[4-(4-iodophenyl)-1-oxobutyl]-, 1,1-dimethylethyl ester
[CAS]

2703051-80-1
[Synonyms]

L-Lysine, N6-[4-(4-iodophenyl)-1-oxobutyl]-, 1,1-dimethylethyl ester
[Molecular Formula]

C20H31IN2O3
[MOL File]

2703051-80-1.mol
[Molecular Weight]

474.38
Chemical PropertiesBack Directory
[Boiling point ]

558.8±50.0 °C(Predicted)
[density ]

1.332±0.06 g/cm3(Predicted)
[form ]

Oil
[pka]

16.26±0.46(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Lys(CO-C3-p-I-Ph)-O-tBu is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules. Lys(CO-C3-p-I-Ph)-O-tBu can increase the residence time of PSMA ligand in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-O-tBu also reduces salivary gland absorption, possibly extending the half-life of the active compound. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC)[1][2].
[References]

[1] Sun M, et al. Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapies for Prostate Cancer. Curr Oncol Rep. 2021 Mar 29;23(5):59. DOI:10.1007/s11912-021-01042-w
[2] Zitzmann-Kolbe S, et al., Preclinical evaluation of an actinium-225 labeled PSMA-targeting small molecule (225Ac-PSMA-Trillium (BAY 3563254)) for the treatment of metastatic castration resistant prostate cancer (mCRPC)[J]. Cancer Research, 2024, 84(6_Supplement): 6033-6033.
2703051-80-1 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: Guangzhou Yansai Biological Products Co., Ltd.  
Tel: 13710209565
Website: www.approvedhomemanagement.com/ShowSupplierProductsList509127/0_EN.htm
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