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ChemicalBook >> CAS DataBase List >> 2-TrifluoroMethyl-2'-Methoxychalcone

2-TrifluoroMethyl-2'-Methoxychalcone

2-TrifluoroMethyl-2'-Methoxychalcone price.
  • $57 - $2120
  • Product name: 2-TrifluoroMethyl-2'-Methoxychalcone
  • CAS: 1309371-03-6
  • MF: C17H13F3O2
  • MW: 306.28
  • EINECS:
  • MDL Number:
  • Synonyms:2-Propen-1-one, 1-(2-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-, (2E)-;(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one;2-Trifluoromethyl-2'-methoxychalcone;Nrf2 Activator;2-Trifluoromethyl-2′-methoxychalcone, CAS 1309371-03-6
11 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • Medical Isotopes, Inc.
  • TRC
Package
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 5mg(solution)
  • 10mg(solution)
  • 50mg(solution)
  • 100mg(solution)
  • ManufacturerAK Scientific
  • Product number5704DK
  • Product description2-Trifluoromethyl-2'-methoxychalcone
  • Packaging50mg
  • Price$586
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3283
  • Product description2-Trifluoromethyl-2'-methoxychalcone
  • Packaging5mg(solution)
  • Price$62
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3283
  • Product description2-Trifluoromethyl-2'-methoxychalcone
  • Packaging10mg(solution)
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3283
  • Product description2-Trifluoromethyl-2'-methoxychalcone
  • Packaging50mg(solution)
  • Price$499
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3283
  • Product description2-Trifluoromethyl-2'-methoxychalcone
  • Packaging100mg(solution)
  • Price$874
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11881
  • Product description2-Trifluoromethyl-2'-methoxychalcone ≥98%
  • Packaging5mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11881
  • Product description2-Trifluoromethyl-2'-methoxychalcone ≥98%
  • Packaging10mg
  • Price$107
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11881
  • Product description2-Trifluoromethyl-2'-methoxychalcone ≥98%
  • Packaging50mg
  • Price$437
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11881
  • Product description2-Trifluoromethyl-2'-methoxychalcone ≥98%
  • Packaging100mg
  • Price$765
  • Updated2024-03-01
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number62342
  • Product description2-Trifluoromethyl-2??-methoxychalcone
  • Packaging250mg
  • Price$2120
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberT791320
  • Product description2-Trifluoromethyl-2''-methoxychalcone
  • Packaging250mg
  • Price$1175
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5704DK 2-Trifluoromethyl-2'-methoxychalcone 50mg $586 2021-12-16 Buy
ApexBio Technology C3283 2-Trifluoromethyl-2'-methoxychalcone 5mg(solution) $62 2021-12-16 Buy
ApexBio Technology C3283 2-Trifluoromethyl-2'-methoxychalcone 10mg(solution) $119 2021-12-16 Buy
ApexBio Technology C3283 2-Trifluoromethyl-2'-methoxychalcone 50mg(solution) $499 2021-12-16 Buy
ApexBio Technology C3283 2-Trifluoromethyl-2'-methoxychalcone 100mg(solution) $874 2021-12-16 Buy
Cayman Chemical 11881 2-Trifluoromethyl-2'-methoxychalcone ≥98% 5mg $57 2024-03-01 Buy
Cayman Chemical 11881 2-Trifluoromethyl-2'-methoxychalcone ≥98% 10mg $107 2024-03-01 Buy
Cayman Chemical 11881 2-Trifluoromethyl-2'-methoxychalcone ≥98% 50mg $437 2024-03-01 Buy
Cayman Chemical 11881 2-Trifluoromethyl-2'-methoxychalcone ≥98% 100mg $765 2024-03-01 Buy
Medical Isotopes, Inc. 62342 2-Trifluoromethyl-2??-methoxychalcone 250mg $2120 2021-12-16 Buy
TRC T791320 2-Trifluoromethyl-2''-methoxychalcone 250mg $1175 2021-12-16 Buy

Properties

Boiling point :395.6±42.0 °C(Predicted)
Density :1.238±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤11mg/ml in ethanol;5mg/ml in DMSO;14mg/ml in dimethyl formamide
form :solution in acetate.
color :yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Nrf2 activation is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. 2-Trifluoromethyl-2'-methoxychalcone is a potent activator of Nrf2, both in vitro and in mice. Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2'-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1. Furthermore, treatment of mice mice with 50 mg/kg 2-trifluoromethyl-2’-methoxychalcone leads to a 4.5- and 4.6-fold increase in the expression of GCLM and NQO1, respectively, in the small intestine compared to controls.