GN25
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- $34 - $299
- Product name: GN25
- CAS: 1227401-27-5
- MF: C15H14O6S
- MW: 322.33
- EINECS:
- MDL Number:
- Synonyms:GN25;DIIRLGMLDOPLPV-UHFFFAOYSA-N;Propanoic acid, 3-[(1,4-dihydro-5,8-dimethoxy-1,4-dioxo-2-naphthalenyl)thio]-
8 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
Package
- 5mg
- 10mg
- 25mg
- 50mg
- ManufacturerAK Scientific
- Product number3577DG
- Product description3-(5,8-Dimethoxy-1,4-dioxonaphthalen-2-yl)sulfanylpropanoicacid
- Packaging5mg
- Price$136
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4840
- Product descriptionGN25
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4840
- Product descriptionGN25
- Packaging25mg
- Price$169
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4840
- Product descriptionGN25
- Packaging50mg
- Price$299
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10948
- Product descriptionGN25 ≥98%
- Packaging5mg
- Price$34
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10948
- Product descriptionGN25 ≥98%
- Packaging10mg
- Price$64
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10948
- Product descriptionGN25 ≥98%
- Packaging25mg
- Price$150
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10948
- Product descriptionGN25 ≥98%
- Packaging50mg
- Price$264
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3577DG | 3-(5,8-Dimethoxy-1,4-dioxonaphthalen-2-yl)sulfanylpropanoicacid | 5mg | $136 | 2021-12-16 | Buy |
| ApexBio Technology | C4840 | GN25 | 10mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | C4840 | GN25 | 25mg | $169 | 2021-12-16 | Buy |
| ApexBio Technology | C4840 | GN25 | 50mg | $299 | 2021-12-16 | Buy |
| Cayman Chemical | 10948 | GN25 ≥98% | 5mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 10948 | GN25 ≥98% | 10mg | $64 | 2024-03-01 | Buy |
| Cayman Chemical | 10948 | GN25 ≥98% | 25mg | $150 | 2024-03-01 | Buy |
| Cayman Chemical | 10948 | GN25 ≥98% | 50mg | $264 | 2024-03-01 | Buy |
Properties
Boiling point :608.4±55.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤0.25mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
form :crystalline solid
pka :4.24±0.10(Predicted)
color :Light yellow to orange
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤0.25mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
form :crystalline solid
pka :4.24±0.10(Predicted)
color :Light yellow to orange
Safety Information
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Description
The tumor suppressor gene, p53, is often mutated or suppressed in human cancers. Oncogenic K-Ras has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. GN25 is a 2-thio-dimethoxy naphthoquinone analog that blocks Snail binding to p53 and induces p53 expression in cancer cells in a K-Ras dependent manner. At 10 μM, GN25 significantly reduces cell proliferation in K-Ras mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression.Suppliers and manufacturers
Aladdin Scientific
Amadis Chemical Company Limited
MedBioPharmaceutical Technology Inc
Shanghai Universal Biotech Co.,Ltd
Shanghai Taopu Industrial Co., LTD
Shanghai Yiyan Biotechnology Co. , Ltd.
Shanghai Yifei Biotechnology Co. , Ltd.
RD International Technology Co., Limited
Cayman Chemical Company
ApexBio Technology