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ChemicalBook >> CAS DataBase List >> JW55

JW55

JW55 price.
  • $68 - $7030
  • Product name: JW55
  • CAS: 664993-53-7
  • MF: C25H26N2O5
  • MW: 434.48
  • EINECS:-0
  • MDL Number:MFCD03863265
  • Synonyms:JW55;N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide;N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE;N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide;JW55 N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide;JW 55, >=98%;N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid;Tankyrase1/2 Inhibitor IV, JW55
32 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 5mg
  • 10
  • 10mg
  • 2x10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1000mg
  • 5g
  • 10g
  • ManufacturerAK Scientific
  • Product number3754AH
  • Product descriptionN-[4-[([[4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl]amino)carbonyl]phenyl]-2-furamide
  • Packaging5mg
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3754AH
  • Product descriptionN-[4-[([[4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl]amino)carbonyl]phenyl]-2-furamide
  • Packaging10mg
  • Price$158
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA533890
  • Product descriptionJW55 98+%
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA533890
  • Product descriptionJW55 98+%
  • Packaging50mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0002076
  • Product descriptionJW-55 95.00%
  • Packaging10MG
  • Price$240.45
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4529
  • Product descriptionJW55
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4529
  • Product descriptionJW55
  • Packaging50mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1922
  • Product descriptionJW55 99%
  • Packaging2x10mg
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181033
  • Product descriptionJW55 >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181033
  • Product descriptionJW55 >98%
  • Packaging250mg
  • Price$1030.2
  • Updated2021-12-16
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  • ManufacturerBiorbyt Ltd
  • Product numberorb181033
  • Product descriptionJW55 >98%
  • Packaging1000mg
  • Price$1949.9
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16260
  • Product descriptionJW 55 ≥98%
  • Packaging5mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16260
  • Product descriptionJW 55 ≥98%
  • Packaging10mg
  • Price$121
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16260
  • Product descriptionJW 55 ≥98%
  • Packaging25mg
  • Price$201
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM182424
  • Product descriptionN-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamide 98%
  • Packaging100mg
  • Price$317
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1757
  • Product descriptionJW55 99.94%
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3754AH N-[4-[([[4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl]amino)carbonyl]phenyl]-2-furamide 5mg $115 2021-12-16 Buy
AK Scientific 3754AH N-[4-[([[4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl]amino)carbonyl]phenyl]-2-furamide 10mg $158 2021-12-16 Buy
Ambeed A533890 JW55 98+% 10mg $75 2021-12-16 Buy
Ambeed A533890 JW55 98+% 50mg $190 2021-12-16 Buy
American Custom Chemicals Corporation INB0002076 JW-55 95.00% 10MG $240.45 2021-12-16 Buy
ApexBio Technology A4529 JW55 10mg $90 2021-12-16 Buy
ApexBio Technology A4529 JW55 50mg $300 2021-12-16 Buy
Axon Medchem Axon1922 JW55 99% 2x10mg $165 2021-12-16 Buy
Biorbyt Ltd orb181033 JW55 >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb181033 JW55 >98% 250mg $1030.2 2021-12-16 Buy
Biorbyt Ltd orb181033 JW55 >98% 1000mg $1949.9 2021-12-16 Buy
Cayman Chemical 16260 JW 55 ≥98% 5mg $68 2024-03-01 Buy
Cayman Chemical 16260 JW 55 ≥98% 10mg $121 2024-03-01 Buy
Cayman Chemical 16260 JW 55 ≥98% 25mg $201 2024-03-01 Buy
Chemenu CM182424 N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamide 98% 100mg $317 2021-12-16 Buy
ChemScene CS-1757 JW55 99.94% 10mg $108 2021-12-16 Buy

Properties

Boiling point :572.6±50.0 °C(Predicted)
Density :1.235±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :DMSO: soluble15mg/mL, clear
pka :12.41±0.70(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC50s = 1.9 and 0.83 μM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC50 = 470 nM). It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro.